Uncoupling protein 1 (Ucp1) is the key component of β-adrenergically controlled nonshivering thermogenesis in brown adipocytes. This process combusts stored and nutrient energy as heat. Cold exposure not only activates Ucp1-mediated thermogenesis to maintain normothermia but also results in adaptive …

2015年12月29日 · In inguinal white adipose tissue (iWAT) of mice fed a high-fat diet (HFD), Ucp1 level decreases concomitantly with increases in Cnot7 and its interacting partner Tob. HFD-fed mice lacking Cnot7 and Tob express elevated levels of Ucp1 mRNA in iWAT and are resistant to diet-induced obesity.

2024年11月12日 · These results demonstrate that SerpinA1 is an important hepatokine that improves obesity, energy expenditure and glucose metabolism by promoting preadipocyte proliferation and activating...

2011年1月1日 · In this overview, we focus on the mRNA and protein expression of Ucp1 in response to feeding high-fat diets (HFDs) because the existence or nonexistence of a positive correlation has repeatedly been used to argue for or against a …

TEL增加了iWAT中Ucp1+米色脂肪细胞含量，与Ucp1和Cidea蛋白水平升高一致（图6k-6l）。 总之，这些数据表明TEL作为BCAT2抑制剂，通过促进iWAT褐变和能量消耗，保护小鼠免受HFD诱导的肥胖。

2025年3月7日 · Stimulating adipose tissue thermogenesis has emerged as a promising strategy for combating obesity, with uncoupling protein 1 (UCP1) playing a central role in this process. However, the mechanisms that suppress adipose thermogenesis and energy dissipation in obesity are not fully understood.

2024年1月9日 · Here, we show that the cAMP-binding protein EPAC1 is a central regulator of adaptive BAT growth. In vivo, selective pharmacological activation of EPAC1 increases BAT mass and browning of white fat,...

2015年12月29日 · Uncoupling protein 1 (Ucp1) contributes to thermogenesis, and its expression is regulated at the transcriptional level. Here, we show that Ucp1 expression is also regulated post-transcriptionally. In inguinal white adipose tissue (iWAT) of mice fed a high-fat diet (HFD), Ucp1 level decreases concomi …

在接触 HFD 之前和期间，干预措施诱导脂肪组织中Ucp-1 的表达。 Ucp-1诱导伴随着较高的PGC1a和PRDM16表达。 与 HFD 组相比，葡萄糖耐量和胰岛素敏感性得到改善，同时血清胆固醇、甘油三酯、游离脂肪酸、胰岛素、瘦素、抵抗素、成纤维细胞生长因子 21、丙氨酸转氨酶、天冬氨酸转氨酶和脂联素水平降低。 HFD 相关的全身炎症（IL-1β 和 TNF-α）增加，脂肪组织炎症（F4/80、IL-1β、TNF-α、IL-6）减少。 对 Ucp-1 报告小鼠模型的研究表明，早期使用 …

2025年2月28日 · A Representative image of UCP1 immunostaining in vWAT and BAT sections of SIRPα ΔMac and SIRPα loxp/loxp mice fed with HFD for 16 weeks (left), and the quantification of UCP1-positive area in vWAT (middle) and BAT (right) is shown. n = 6 per group.