2022年11月24日 · 今年10月发表在Cancer Cell（IF:38.58）上的最新研究就是关于ER的转导因子—— 内质网应激 相关激酶 PERK 。研究结果表明缺失PERK会诱导细胞的凋亡，从而促进抗肿瘤免疫。这项研究明确了PERK在黑色素瘤中的免疫治疗潜力。 01什么是PERK？

2020年8月8日 · 细胞能够感知ER内错误折叠或未折叠蛋白质累积，通过三条信号通路缓解ER应激，介导这一调控的信号通路称为未折叠蛋白反应 (unfolded protein response, UPR)。 （可以把新生多肽链想象成→需要接受九年义务教育的学生；内质网→学校，负责把学生们教育好了再送出去；内质网应激→校园里中不良少年过多，学校秩序混乱无法管理，启动教育检查组→未折叠蛋白反应相关分子，重拳出击，净化校园风气，维持校园秩序） UPR激活过程：

The unfolded protein response (UPR) is a cellular stress response related to the endoplasmic reticulum (ER) stress. [1] It has been found to be conserved between mammalian species, [2] as well as yeast [1] [3] and worm organisms. The UPR is activated in response to an accumulation of unfolded or misfolded proteins in the lumen of the

The activation of the UPR involves three signaling pathways, IRE1, PERK and ATF6, which all play vital roles in returning protein homeostasis to levels seen in non-stressed cells. IRE1 is the best studied of the three pathways, as it is the only pathway present in Saccharomyces cerevisiae .

2024年4月18日 · In this study, we demonstrate cross talk between the IRE1 and PERK branches of the UPR, wherein IRE1 via XBP1s signaling helps to sustain PERK expression during prolonged ER stress. Our...

2020年5月26日 · Under endoplasmic reticulum (ER) stress, three major UPR branches are activated: (1) PERK phosphorylates eukaryotic translation initiation factor 2 subunit-α (eIF2α), reducing the overall...

2019年11月6日 · There are three key UPR signal activators—IRE1, PERK and ATF6—which give rise to separate branches of the response 1, 2, 3, 4. The activator proteins traverse the ER membrane, presenting a...

2024年6月25日 · Here, we report a strategy of visualizing unfolded protein accumulation in the ER lumen in living cells by employing an engineered ER stress sensor, PERK, which forms fluorescence puncta upon unfolded protein binding, in a fast and reversible way.

2018年3月13日 · ER-stress-associated SIMH is regulated by the PERK arm of the UPR and activated by eIF2α phosphorylation-dependent translation attenuation. We show that PERK-regulated SIMH is a protective mechanism to prevent pathologic mitochondrial fragmentation and promote mitochondrial metabolism in response to ER stress.

2021年6月11日 · 近日，我校生命科学学院屈良鹄教授课题组以成肌细胞诱导的骨骼肌分化模型为对. 未折叠蛋白反应（unfolded protein response， UPR）是一种进化保守的细胞内稳态信号通路，包含PERK、IRE1和ATF6等三条信号通路。 UPR在体细胞生理和病理过程中发挥重要功能，同时也参与了多种 干细胞 分化和个体发育的过程，但其中复杂而深奥的调控机制仍有待解析。 近日，我校生命科学学院屈良鹄教授课题组以成肌细胞诱导的骨骼肌分化模型为对象，揭示了UPR …