USP30 plays an essential role in several cellular events, such as the PINK1/Parkin-mediated mitophagy, pexophagy, BAX/BAK-dependent apoptosis, and IKKβ–USP30–ACLY-regulated lipogenesis/tumorigenesis, and is tightly regulated by post-translational modification including phosphorylation and mono-ubiquitination.

2024年12月25日 · USP30 (Ubiquitin Specific Peptidase 30) is a Protein Coding gene. Diseases associated with USP30 include Autism Spectrum Disorder and Parkinson Disease 25, Autosomal Recessive Early-Onset, With Impaired Intellectual Development. Among its related pathways are Selective autophagy and Deubiquitination.

Ubiquitin-specific protease 30 (USP30), as a deubiquitinating enzyme, not only participates in the regulation of mitochondrial dynamics through deubiquitinating fusion and fission proteins such as mitofusin 1/2 (Mfn1/2) and dynamin-related protein 1 (Drp1), but also deubiquitinates E3 ubiquitin ligase Parkin, ubiquitin (Ub) and voltage ...

2023年11月13日 · Here we show that loss of USP30 in Usp30 knockout mice protects against behavioral deficits and leads to increased mitophagy, decreased phospho-S129 αSyn, and attenuation of SN dopaminergic...

2024年1月15日 · Our findings demonstrate that USP30 inhibition is a promising approach to boost mitophagy and improve cellular health, also in parkin-deficient cells, and support the potential relevance of...

USP-30: 一种ubiquitin抑制剂药物，由Ensemble Therapeutics Corp. (Ensemble Therapeutics Corp.)公司最早进行研发，目前全球最高研发状态为终止，作用机制: ubiquitin抑制剂 (泛素蛋白抑制剂)，治疗领域: 肿瘤,神经系统疾病,内分泌与代谢疾病。

泛素特异性蛋白酶 30 (USP30) 是一种去泛素化酶 (DUB)，属于 USP 亚家族，由于其独特的跨膜结构域，发现它位于线粒体外膜和过氧化物酶体中。 结构研究表明，USP30 采用独特的催化三联体和分子结构来优先切割 Lys6 连接的泛素链。

Book *Note that USP did not begin posting commentary on the USP website until Supplement 1 to USP 30–NF 25

USP30 is an integral protein of the outer mitochondrial membrane that counteracts PINK1 and Parkin-dependent mitophagy following acute mitochondrial depolarisation. Here, we use two distinct mitophagy reporter systems to reveal tonic suppression by USP30, of a PINK1-dependent component of basal mitophagy in cells lacking detectable Parkin.

2022年3月3日 · Ubiquitin-specific protease 30 (USP30) is a deubiquitinating enzyme (DUB) belonging to the USP subfamily, which was found localized in the mitochondrial outer membrane and peroxisomes owing to its unique transmembrane domain. Structural study revealed that USP30 employed a unique catalytic triad and …