Damage sensor role of UV-DDB during base excision repair
2019年7月22日 · Single-molecule real-time imaging revealed that UV-DDB forms transient complexes with OGG1 or APE1, facilitating their dissociation from DNA. Furthermore, UV-DDB …
Global and transcription-coupled repair of 8-oxoG is initiated by ...
2022年2月21日 · Using two different approaches to introduce 8-oxoG in cells, we show that DDB2 is recruited to 8-oxoG immediately after damage and colocalizes with 8-oxoG glycosylase …
The role of UV-DDB in processing 8-oxoguanine during base …
This review first discusses biochemical studies demonstrating how UV-DDB stimulates human 8-oxoG glycosylase (OGG1), MUTYH, and apurinic/apyrimidinic (AP) endonuclease (APE1) to …
Lost in the Crowd: How Does Human 8-Oxoguanine DNA Glycosylase 1 (OGG1 ...
In mammalian cells, the modified base is excised by the 8-oxoguanine DNA glycosylase (OGG1), initiating the base excision repair (BER) pathway. OGG1 confronts the massive challenge that …
OGG1，DNA氧化损伤修复者 - 知乎 - 知乎专栏
Recombinant Human N-Glycosylase/OGG1 是一种DNA修复酶，其作为一种修饰酶, 主要具有DNA糖基化酶活性和脱嘌呤/脱嘧啶（apurinic/apyrimidinic，AP）裂解酶活性两种活性。 N-糖 …
UV-DDB as a General Sensor of DNA Damage in Chromatin
2023年6月15日 · Moreover, we have shown that UV-DDB can assist chromatin decompaction, facilitating access of OGG1 to 8-oxoguanine damage in telomeres. This review summarizes …
In Vitro Fluorogenic Real-time Assay of the Repair of Oxidative …
2015年7月7日 · Here we report on the design and properties of fluorogenic probes that directly report on OGG1 (and bacterial homologue Fpg) activity in real time as the oxidized base is …
Roles for the 8-Oxoguanine DNA Repair System in Protecting …
UV-DDB is well known for recognizing UV photoproducts and initiating the global genome nucleotide excision repair pathway. The discovery that UV-DDB binds to 8-oxoG lesions and …
Damage sensor role of UV-DDB during base excision repair
Single-molecule real-time imaging revealed that UV-DDB forms transient complexes with OGG1 or APE1, facilitating their dissociation from DNA. Furthermore, UV-DDB moves to sites of 8 …
Phloroglucinol Attenuates Ultraviolet B-Induced 8-Oxoguanine …
2021年1月1日 · We investigated whether phloroglucinol (1,3,5-trihydroxybenzene), by enhancing the expression and activity of 8-oxoG DNA glycosylase 1 (Ogg1), had an effect on the capacity …