2024年12月25日 · UBE2L3 (Ubiquitin Conjugating Enzyme E2 L3) is a Protein Coding gene. Diseases associated with UBE2L3 include Papilloma and Systemic Lupus Erythematosus. …

UBE2L3 is primarily known for its role in the cell cycle. Specifically, UBE2L3 manages cell cycle regulatory protein levels via the ubiquitin proteolytic pathway (UPP) during the G1/S transition …

2023年7月20日 · Here we report that deletion of Ube2l3 in mice reduces pro-IL-1β turnover in macrophages, leading to excessive mature IL-1β production, neutrophilic inflammation and …

UBE2L3, an E2 enzyme, is thought to be an indirect target of IL-1β secretion by binding to ubiquitin ligases such as TRIM21. However, its role in psoriasis remains unknown. In this …

UBE2L3, also called UBcH7, is one of many E2 ubiquitin conjugating enzymes that participate in the ubiquitination of many substrate proteins and regulate many signaling pathways, such as …

2013年9月24日 · As increased UBE2L3 expression enhances NF-κB activation, and increased levels of NF-κB activity are linked to inflammatory and autoimmune diseases, the data suggest …

UBE2L3，也称为 UBcH7，是众多 E2 泛素结合酶之一，参与许多底物蛋白的泛素化并调节许多信号通路，例如 NF-κB、GSK3β/p65 和 DSB 修复通路。 对UBE2L3的研究发现，其在多种疾 …

UBE2L3 regulates TLR7-induced B cell autoreactivity in Systemic Lupus Erythematosus. UBE2L3 promotes squamous cell carcinoma progression in the oral cavity and hypopharynx via …

2015年2月2日 · UBE2L3 is an E2 ubiquitin-conjugating enzyme, specially adapted to function with HECT and RING-in-between-RING (RBR) E3 ligases, including HOIL-1 and HOIP, …

Ubiquitination involves at least three classes of enzymes: ubiquitin-activating Enzymes (E1s), ubiquitin-conjugating Enzymes (E2s) and ubiquitin-protein ligases (E3s). This gene encodes a …