2024年12月25日 · UBTF (Upstream Binding Transcription Factor) is a Protein Coding gene. Diseases associated with UBTF include Neurodegeneration, Childhood-Onset, With Brain Atrophy and Rare Syndromic Intellectual Disability. Among its related pathways are RNA Polymerase I Promoter Opening and RNA Polymerase I Transcription Termination.

上游结合因子1（Upstream binding factor 1，缩写UBF1）是一种由人类基因UBTF所编码的蛋白质。UBTF是18S、5.8S和28S的核糖体RNA的转录所必须的转录因子，和SL1因子（一个四聚体，包括一个TBP，即TATA结合蛋白和3个转录辅助因子TAF1）共同起作用。

UBTF is a transcription factor required for expression of the 18S, 5.8S, and 28S ribosomal RNAs, along with SL1 (a complex of TBP (MIM 600075) and three TBP-associated factors or 'TAFs') [citation needed]. UBTF is a nucleolar phosphoprotein with both …

核仁转录因子1 （Nucleolar transcription factor 1）又叫 上游结合转录因子 （Upstream binding transcription factor，缩写 UBTF）或 上游结合因子1 （Upstream binding factor 1，缩写 UBF1）是一种由人类 基因 UBTF 所编码的 蛋白质 [1][2]。 UBTF是 18S 、 5.8S 和 28S的核糖体RNA 的转录所必须的转录因子，和SL1因子（一个四聚体，包括一个 TATA结合蛋白 和3个转录辅助因子 TAF1 （英语：TAF1））共同起作用。 在人体中存在94和97kD的两种UBF多肽链。

The upstream binding factor 1 (UBF1) is one of the proteins in a complex that regulates the activity of RNA polymerase I, which controls the rate of ribosomal RNA (rRNA) synthesis. We have shown previously that insulin receptor substrate-1 (IRS-1) can translocate to the nuclei and nucleoli of cells and bind UBF1.

2020年6月12日 · Recently, we demonstrated that a significant pool of ECT2 localizes to the nucleolus of non-small-cell lung cancer (NSCLC) cells, where it binds the transcription factor upstream binding factor 1 (UBF1) on the promoter regions of ribosomal DNA (rDNA) and activates rDNA transcription, transformed cell growth, and tumor formation.

The human ribosomal RNA promoter contains two distinct control elements (UCE and core) both of which are recognized by the sequence-specific DNA binding protein UBF1, which has now been purified to apparent homogeneity. The purified factor activates RNA polymerase I (RNA pol I) transcription through direct interactions with either control element.

2008年12月12日 · Thus, UBF1 levels regulate active rRNA gene chromatin during growth and differentiation. Ribosome biogenesis plays an essential role in growth control, and transcription of the 45S precursor of the ribosomal RNA (rRNA) by RNA polymerase I (Pol I) is limiting for proliferation in most cellular systems (Jorgensen and Tyers, 2004).

2020年6月6日 · Biochemical and MS-based analyses revealed that protein kinase Cι (PKCι) directly phosphorylates UBF1 at Ser-412, thereby generating a phosphopeptide-binding epitope that binds the ECT2 BRCT domain.

2015年1月5日 · Our data demonstrate that UBF1/2 bind highly active Pol II-transcribed genes and mediate their expression without recruiting Pol I. Furthermore, we reported ChIP-sequencing analysis of UBF1/2 in immortalized human epithelial cells and their isogenically matched transformed counterparts.