Stress response silencing by an E3 ligase mutated in ... - Nature
2024年1月31日 · We recently discovered that UBR4, an E3 ligase known for its role in the N-end rule pathway 9, helps degrade aggregation-prone nascent polypeptides 10. As mutations in …
A Key Role for the Ubiquitin Ligase UBR4 in Myofiber Hypertrophy …
2019年7月30日 · In Drosophila and mouse myofibers, loss of UBR4 induces hypertrophy via decreased ubiquitination and degradation of a core set of target proteins, including the …
Insights into the recognition mechanism in the UBR box of UBR4 …
2023年11月29日 · Our findings suggest that the UBR box of UBR4 recognizes type-1 N-terminal arginine and type-2 N-terminal amino acids containing an aromatic ring, such as tyrosine, …
A Ubiquitination Cascade Regulating the Integrated Stress …
2023年3月1日 · We used gene essentiality measurements in 1,086 cancer cell lines to identify selective coessentiality modules and found that a ubiquitin ligase complex composed of UBA6, …
UHRF1/UBE2L6/UBR4-mediated ubiquitination regulates EZH2
2023年3月11日 · Biochemical assays and animal studies demonstrated that in LPCs, the E2-conjugating enzyme UBE2L6 depletes EZH2 protein in cooperation with UBR4, an E3 ligase, …
2024年12月18日 · To elucidate how these proteins interact to assemble an eficient yet tightly regulated E4 ligase, we reconstituted the UBR4/KCMF1/CALM1 complex and examined its …
UBR4 Gene - GeneCards | UBR4 Protein | UBR4 Antibody
2024年12月25日 · UBR4 (Ubiquitin Protein Ligase E3 Component N-Recognin 4) is a Protein Coding gene. Diseases associated with UBR4 include Alternating Hemiplegia Of Childhood 2 …
Convergence of orphan quality control pathways at a ubiquitin …
2025年2月20日 · Epistasis analysis in cells and reconstitution studies in vitro show that the UBR4-KCMF1 complex acts downstream of a priming ubiquitin ligase that first mono-ubiquitinates …
UBR4 (Ubiquitin Ligase E3 Component N-Recognin 4)
2017年1月1日 · A recent study has shed some light on a potential mechanism by which p600/UBR4 impacts autophagy. In HEK293 cells, p600/UBR4 can form a multi-protein …
Cell综述：三种泛素连接酶 - 生物通
2016年4月8日 · Ubiquitination requires the sequential action of three enzymes: E1 (ubiquitin-activating enzymes), E2 (ubiquitin-conjugating enzymes), and E3 (ubiquitin ligases).
2023年5月9日 · Herein, we identify and characterize, at a biochemical and structural level, a distinct E3 module within human UBR4 consisting of a novel “hemiRING” zinc finger, a helical …
UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4
2024年1月5日 · UBR4 is a 574 kDa E3 ligase (E3) of the N-degron pathway with roles in neurodevelopment, age-associated muscular atrophy and cancer. The catalytic module that …
UBE2A and UBE2B are recruited by an atypical E3 ligase module in UBR4 …
UBR4 is a 574 kDa E3 ligase (E3) of the N-degron pathway with roles in neurodevelopment, age-associated muscular atrophy and cancer. The catalytic module that carries out ubiquitin (Ub) …
Stress response silencing by an E3 ligase mutated in …
We recently discovered that UBR4, an E3 ligase known for its role in the N-end rule pathway 9, helps degrade aggregation-prone nascent polypeptides 10. As mutations in UBR4 cause …
A novel locus for episodic ataxia: UBR4 the likely candidate
2013年8月28日 · UBR4 is an ubiquitin ligase protein that is known to interact with calmodulin, a Ca 2+ protein, in the cytoplasm. It also co-localizes with ITPR1 a calcium release channel that …
A Key Role for the Ubiquitin Ligase UBR4 in Myofiber Hypertrophy …
2019年7月30日 · In Drosophila and mouse myofibers, loss of UBR4 induces hypertrophy via decreased ubiquitination and degradation of a core set of target proteins, including the …
Architecture of the UBR4 complex, a giant E4 ligase central to ...
2024年12月20日 · Our cryo-EM analysis of UBR4 in complex with its cofactors KCMF1 and CALM1 reveals a massive 1.3 MDa ring structure, featuring a central substrate-binding arena …
<br>深入了解UBR4的UBR盒对其特定底物的识别机 …
UBR 亚家族的 E3 连接酶通过泛素-蛋白酶体系统识别并降解 N-降解决定子。 在此，我们研究了 UBR4，它具有识别 2 型 N 降解决定子的独特机制。 结构分析表明，UBR4 的 UBR 盒与其他 …
Substrate ubiquitination occurs through a series of enzymes, including ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s), and E3 ubiquitin ligases (E3s). E1 …