UBR5 Is Coamplified with MYC in Breast Tumors and Encodes an …
2020年4月1日 · Of direct cancer relevance, MYC and UBR5 genes were coamplified in MYC-driven human cancers. Functionally, UBR5 suppressed MYC-mediated apoptosis in p53 …
Identification of the HECT E3 ligase UBR5 as a regulator of MYC ...
2020年11月18日 · We demonstrate interaction of UBR5 with MYC and reduced K48-linked ubiquitination of MYC upon loss of UBR5 in cells. Interestingly, in cancer cell lines with …
Identification of the HECT E3 ligase UBR5 as a regulator of MYC ...
2020年11月18日 · Our screen identifies UBR5, an E3 ligase of the HECT-type family, as a novel regulator of MYC degradation. Even in the presence of the well-described and functional MYC …
泛素蛋白链接酶E3 识别素5,(ubiquitin protein ligase E3 component n-recognin 5, UBR5, 又名EDD1) 具有独特的结构特征,参与了DNA损伤反应、代谢、转录和凋亡的调节,在癌症和发育过 …
Orphan quality control shapes network dynamics and gene …
2023年7月20日 · Here, we identify the E3 ligase UBR5 as a signaling hub that helps degrade unpaired subunits of multiple transcriptional regulators that act within a network centered on …
The role of UBR5 in tumor proliferation and oncotherapy
2024年5月15日 · UBR5 is a crucial Ub ligase that plays a pivotal role in regulating protein degradation and signaling pathways in cell biology. The expression level of UBR5 elevates in …
在乳腺肿瘤中，UBR5与MYC共同扩增，并编码泛素 ... - X-MOL
UBR5 is co-amplified with MYC in breast tumors and encodes an ubiquitin ligase that limits MYC-dependent apoptosis. For maximal oncogenic activity, cellular MYC protein levels need to be …
Control of MYC-dependent apoptotic threshold by a co ... - bioRxiv
2019年1月8日 · UBR5 effects on MYC protein stability are independent on N-terminal FBW7 degron of MYC. Endogenous UBR5 inhibition induces MYC protein expression and activates …
UBR5 ubiquitin protein ligase E3 component n-recognin 5
2025年2月9日 · Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages. UBR5 Is Coamplified with MYC in Breast Tumors …
征服MYC：曙光初现|降解剂|蛋白质|二聚体|细胞|药物|靶向|-健康界
2022年11月25日 · 加州大学伯克利分校的一个团队刚刚在BioRxiv上展示了E3连接酶UBR5如何降解MYC和其他转录因子，为MYC靶向降解剂提供了可能的替代途径。 Omega Therapeutics正 …