2020年8月27日 · Our finding revealed that UDCA exerted obviously favorable influence on hepatic steatosis in NAFLD rats by activating AMP-activated protein kinase (AMPK). Mechanistic studies indicated UDCA inhibited apoptosis and improved autophagy by influencing Bcl-2/Beclin-1 and Bcl-2/Bax complex interaction.

2017年8月1日 · UDCA induced the activation of AMP-activated protein kinase (AMPK) and p38 in mouse CD4 + T cells. UDCA suppressed T helper (Th)17 differentiation through upregulation of small heterodimer partner interacting leucine zipper protein (SMILE) and transcriptional activity of peroxisome proliferator-activated receptor (PPAR)γ.

2016年11月15日 · Our results showed that, both CDCA and UDCA significantly induced time- and concentration-dependent reduction in AMPK phosphorylation in SCRHs. Despite having different effects on FXR activation, CDCA and UDCA both inhibited EE-induced AMPK activation, accompanied with the up-regulation of FXR and its downstream bile acid transporters.

2021年1月10日 · UDCA repaired mitochondrial dysfunction, promoted autophagy deregulation, and inhibited apoptosis - the three interactive molecular events essential for controlling neuronal survival in PD, involving the activation of AMPK/mTOR/ULK1 and PINK1/Parkin pathways.

2014年1月1日 · In this study, UDCA strongly increased AMPK phosphorylation, and UDCA-mediated SMILE gene expression was blocked by repression of AMPK signaling. However, the downstream effectors of AMPK signaling to induce SMILE gene expression remain unknown.

证实UDCA通过控制AMPK或p38活性上调了SMILE的表达和PPARγ的转录活性。 结论在本研究中，提出了通过AMPK激活UDCA诱导SMILE在类风湿关节炎小鼠以及其他自身免疫性疾病中的治疗作用。

It was confirmed that UDCA upregulated the expression of SMILE and transcriptional activity of PPARγ via controlling AMPK or p38 activity. Conclusions: In the present study, the therapeutic effect of UDCA inducing SMILE through AMPK activation in rheumatoid arthritis mouse as well as other autoimmune disease was proposed.

2016年4月1日 · In rat primary hepatocytes, UDCA significantly inhibited EE-induced AMPK activation and down-regulation of FXR and bile acid transporters. UDCA rapidly and dose-dependently induced phosphorylation of protein kinase A (PKA), which was correlated to its effect on inhibition of EE-induced AMPK activation and down-regulation of FXR expression.

2020年6月1日 · Our finding revealed that UDCA exerted obviously favorable influence on hepatic steatosis in NAFLD rats by activating AMP-activated protein kinase (AMPK). Mechanistic studies indicated UDCA...

2021年2月1日 · However, phosphorylation of AMPK by different bile acids (i.e. CDCA and UDCA) appears to be dose- and time-dependent as early time points and higher concentrations reduce AMPK phosphorylation [62].