2024年12月25日 · UFD1 (Ubiquitin Recognition Factor In ER Associated Degradation 1) is a Protein Coding gene. Diseases associated with UFD1 include Digeorge Syndrome and Velocardiofacial Syndrome. Among its related pathways are Translesion synthesis by Y family DNA polymerases bypasses lesions on DNA template and Cellular responses to stimuli.

由该基因编码的蛋白质与其他两种蛋白质形成复合物，即核蛋白定位 4 和含有 valosin 的蛋白质，该复合物是泛素化蛋白质降解所必需的。 此外，该复合物控制有丝分裂纺锤体的分解和有丝分裂后封闭核膜的形成。 该基因的突变与 Catch 22 综合征以及心脏和颅面缺陷有关。 可变剪接导致编码不同异构体的多个转录变体。 已在 18 号染色体上鉴定出一个相关的假基因。 [RefSeq 提供，2009 年 6 月]

2019年12月13日 · Ufd1 occupies a hydrophobic groove of the Mpr1/Pad1 N-terminal (MPN) domain of Npl4, which corresponds to the catalytic groove of the MPN domain of JAB1/MPN/Mov34 metalloenzyme (JAMM)-family...

2007年8月8日 · Here we show that Ufd1 directly interacts with gp78 and functions as a cofactor. Ufd1 enhances the E3 activity of gp78, accelerates the ubiquitination and degradation of reductase, and eventually promotes receptor-mediated uptake of low-density lipoprotein.

This study identifies Ufd1 as a cofactor of gp78, reveals an unappreciated function of Ufd1 in the ubiquitination reaction during endoplasmic reticulum -associated degradation, and illustrates that Ufd1 plays a critical role in cholesterol metabolism.

2011年5月31日 · The ubiquitin-recognition protein Ufd1 facilitates clearance of misfolded proteins through the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway. Here we report that prolonged ER stress represses Ufd1 expression to trigger cell …

Abstract: A fragment of ubiquitin fusion degradation protein (UFD) gene UFD1 was cloned from tomato by reverse transcription‐polymerase chain reaction (RT‐PCR) , and its role in regulation of plant disease and stress resistance was analyzed employing virus‐induced gene silencing (VIGS) technique . The results

Here we show that Ufd1 directly interacts with gp78 and functions as a cofactor. Ufd1 enhances the E3 activity of gp78, accelerates the ubiquitination and degradation of reductase, and eventually promotes receptor-mediated uptake of low-density lipoprotein.

UFD1 蛋白是泛素介导的降解途径中重要的泛素识别组分。 为了研究真核生物中 UFD1 基因的保守性及其分化，鉴定了来自小麦的两个 UFD1 旁系同源物，并分别定位到同源染色体组 6 和 2。 克隆了 TaUFD1a-6B 和 TaUFD1b-2D，这两个基因都由八个内含子和相同的内含子相位组成。 将这些基因与拟南芥、水稻、极地、酵母和哺乳动物中的基因的序列、染色体组织和初级蛋白质结构进行了比较。 序列结构，尤其是对应于 UFD1 基因的第四、第五和第六外显子的序列结构，在这 …

2023年10月4日 · Post-translational ubiquitin-protein conjugates are recognized for degradation by the ubiquitin fusion degradation (UFD) pathway. Several proteins involved in this pathway have been identified. This family includes UFD1, a 40kD protein that is …