2017年7月14日 · What is UGT2B15? The UGT2B15 gene encodes an enzyme responsible for glucuronidation, a phase II metabolic reaction that transforms small lipophilic molecules into water-soluble excretable metabolites.

2024年12月25日 · UGT2B15 (UDP Glucuronosyltransferase Family 2 Member B15) is a Protein Coding gene. Diseases associated with UGT2B15 include Major Depressive Disorder and Anxiety. Among its related pathways are Metapathway biotransformation Phase I and II and Paracetamol ADME.

UDP-glucuronosyltransferase 2B15 is an enzyme that in humans is encoded by the UGT2B15 gene. [5][6] The UGTs are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. UGT2B8 demonstrates reactivity with estriol. See UGT2B4 (MIM 600067). [supplied by OMIM] [6]

UDP-glucuronosyltransferase 2B15 (UGT2B15) is the major enzyme responsible for sipoglitazar glucuronidation in humans: retrospective identification of the UGT isoform by in vitro analysis and the effect of UGT2B15*2 mutation

UGT2B15 genotype is a major determinant for differences in fasting plasma glucose and HbA1c response to sipoglitazar treatment between Type 2 Diabetes mellitus patients, due to related differences in drug exposure.

2013年1月1日 · UDP-glucuronosyltransferase 2B15 (UGT2B15) Is the Major Enzyme Responsible for Sipoglitazar Glucuronidation in Humans: Retrospective Identification of the UGT Isoform by In Vitro Analysis and the Effect of UGT2B15*2 Mutation

UGT2B15 is a member of the uridine diphosphate-glucuronosyltransferase superfamily of endoplasmic reticulum bound membrane proteins responsible for catalyzing the glucuronidation of a large number of endogenous compounds, environmental chemicals, and therapeutic drugs (Court et al., 2002; Nishiyama et al., 2002; Patel et al., 1995).

2016年11月1日 · High UGT2B15 expression is associated with the pathogenesis of gastric cancer. Title: Bioinformatic analysis suggests that UGT2B15 activates the Hippo‑YAP signaling pathway leading to the pathogenesis of gastric cancer.

2015年1月1日 · In the human prostate the androgen-conjugating enzymes UDP-glucuronosyltransferase (UGT)2B15 and 2B17 definitively inactivate DHT, 3α-DIOL and ADT. UGT2B15 conjugates specifically the 17-hydroxyposition of 3α-DIOL and DHT, while UGT2B17 glucuronidates the 3-hydroxyposition of ADT and 17-hydroxypositions of 3α-DIOL and DHT. G: …

Biased expression in liver (RPKM 181.3), gall bladder (RPKM 125.4) and 4 other tissues. 该基因编码一种糖基转移酶，该酶参与代谢和消除有毒化合物，包括内源性和异源性。 该基因在雌激素和雄激素的调节中起作用。 该基因座存在于 4 号染色体上的一组相似基因和假基因中。 [RefSeq 提供，2016 年 8 月]