2024年12月25日 · UGT8 (UDP Glycosyltransferase 8) is a Protein Coding gene. Diseases associated with UGT8 include Niemann-Pick Disease, Type A and Niemann-Pick Disease. Among its related pathways are Sphingolipid metabolism and Metabolism. Gene Ontology (GO) annotations related to this gene include carbohydrate …

2-hydroxyacylsphingosine 1-beta-galactosyltransferase is an enzyme that in humans is encoded by the UGT8 gene. [5][6] Galactocerebrosides are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system and are also present in small amounts in kidney.

该基因编码的蛋白质属于 UDP-糖基转移酶家族。 它催化半乳糖向神经酰胺的转移，这是半乳糖脑苷脂生物合成中的关键酶促步骤，半乳糖脑苷脂是中枢和周围神经系统髓鞘膜中丰富的鞘脂。 已发现该基因的可变剪接转录物变体。 [RefSeq 提供，2011 年 9 月] The protein encoded by this gene belongs to the UDP-glycosyltransferase family.

2010年7月20日 · Our data suggest that UGT8 is a significant index of tumour aggressiveness and a potential marker for the prognostic evaluation of lung metastases in breast cancer.

SOX9-mediated UGT8 expression promotes glycolysis and maintains the malignancy of non-small cell lung cancer. High FA2H and UGT8 transcript levels predict hydroxylated hexosylceramide accumulation in lung adenocarcinoma; UGT8 is a potential prognostic indicator and druggable target of basal-like breast cancer.

UDP-glycosyltransferases (UGTs), important enzymes in biotransformation, control the levels and distribution of numerous endogenous signaling molecules and the metabolism of a wide range of endogenous and exogenous chemicals. The UGT superfamily in mammals consists of the UGT1, UGT2, UGT3, and UGT8 families.

2024年12月10日 · UGT8 is a potential prognostic indicator and druggable target of basal-like breast cancer. Title: Inhibition of UGT8 suppresses basal-like breast cancer progression by attenuating sulfatide-αVβ5 axis.

2022年1月8日 · The transcription factor SOX9 promoted UGT8 expression in NSCLC by recognizing two putative response elements localized on the promoter region of UGT8. Silencing UGT8 impaired glycolysis and reduced the malignancy of NSCLC cells both in vitro and in vivo.

摘要: 目的 研究尿苷二磷酸糖基转移酶8 (UGT8)在胃癌组织中的表达情况, 并探讨其与患者远期预后的关系及对胃癌细胞转移的调控作用。 方法 纳入分析2013年12月-2016年10月于蚌埠医学院第一附属医院行胃癌根治术的109例患者; 采用免疫组化与免疫印迹法检测UGT8在胃癌组织中的表达水平; 运用统计学方法分析胃癌中UGT8表达水平与临床病理参数之间的关系; 采用Cox回归模型和ROC曲线评估影响患者术后5年生存率的独立风险因素和UGT8的诊断效能; 采用GEO数据库 …

2025年1月9日 · 本文将详细介绍ugt8基因的表达模式及其在发育中的作用，通过rna测序和芯片技术分析其在不同组织和发育阶段的表达模式，探讨其在胚胎发育、器官形成及细胞分化中的关键作用，并研究其调控因子及功能验证。