
ULBP1 Gene - GeneCards | ULBP1 Protein | ULBP1 Antibody
2024年12月25日 · ULBP1 (UL16 Binding Protein 1) is a Protein Coding gene. Diseases associated with ULBP1 include Nasopharyngeal Carcinoma and Myeloma, Multiple. Among its related pathways are Innate Immune System and Class I …
ULBP1 - Wikipedia
UL16 binding protein 1 (ULBP1) is a cell surface glycoprotein encoded by ULBP1 gene located on the chromosome 6. [5] [6] ULBP1 is related to MHC class I molecules, but its gene maps outside the MHC locus. [5] [6] The domain structure of ULBP1 differs significantly from those of conventional MHC class I molecules. It does not contain the α3 ...
ULBP1蛋白:NKG2D配体潜力成员,多种血液和实体肿瘤CAR-T治 …
CYAD-01是一种基于NKG2D受体的CAR-T细胞治疗,NKG2D受体可以识别表达在大多数实体瘤和血癌细胞表面的8种不同的配体(MICA、MICB; ULBP1 -ULBP6),导致它可以同时靶向多种不同的癌症。 NKG2D配体(NKG2D Ligands,NKG2DL)在广泛的血液恶性肿瘤中过表达。 据CYAD-01的I期临床数据显示,通过CAR T 细胞疗法 靶向NKG2D配体可提高对这些肿瘤的治疗效果。 ULBP1,作为NKG2D配体成员之一,在多种血液和实体肿瘤中高表达,使用NKG2D …
ULBP1 UL16 binding protein 1 [ (human)] - National Center for ...
2025年2月8日 · ULBP1 binds to the NKG2D receptor and activates multiple signaling pathways in primary natural killer cells. The protein encoded by this gene is a ligand of natural killer group 2, member D (NKG2D), an immune system-activating receptor on NK cells and T-cells.
ULBPs, human ligands of the NKG2D receptor, stimulate tumor immunity ...
2006年8月15日 · ULBPs are human ligands for NKG2D, an activating receptor expressed on natural killer (NK) cells, NK1.1 + T cells, and T cells. ULBPs are expressed by a variety of leukemias, carcinomas, melanomas, and tumor cell lines.
ULBPs, human ligands of the NKG2D receptor, stimulate tumor ... - PubMed
2006年8月15日 · ULBPs are human ligands for NKG2D, an activating receptor expressed on natural killer (NK) cells, NK1.1 (+) T cells, and T cells. ULBPs are expressed by a variety of leukemias, carcinomas, melanomas, and tumor cell lines.
ULBP1 Is Elevated in Human Hepatocellular Carcinoma and Predicts ...
2020年6月23日 · UL-16 binding protein 1 (ULBP1) is a ligand of the activatory receptor Natural Killer cell Group 2 receptor D (NKG2D) and is found as a cell-surface protein on some malignant cells including on human hepatocellular carcinomas. We aimed to explore the biological and clinical significance of NKG2D ligands in the circulation of patients with HCC.
UL16 结合蛋白 1(ULBP1)基因 | MCE - MCE-生物活性分子大师
该基因编码的蛋白质是第 2 组自然杀伤细胞 D 成员 (NKG2D) 的配体,NKG2D 是 NK 细胞和 T 细胞上的一种免疫系统激活受体。 编码的配体与 NKG2D 的结合导致几种信号转导通路的激活,包括 JAK2、STAT5、ERK 和 PI3K 激酶/ Akt。 此外,在巨细胞病毒感染的细胞中,该配体结合 UL16 糖蛋白并被阻止激活免疫系统。 已发现该基因的三个转录变体编码不同的亚型。 [RefSeq 提供,2015 年 11 月]
ULBP1- 信号通路|蛋白抗体-华美生物
ULBP1配体可激活自然杀伤细胞(NK)和CD8+T细胞的NKG2D受体,从而触发免疫杀伤。 研究人员发现,ULBP1在子痫前期(PE)患者外周血外泌体中的高表达,可能会为PE的诊治提供一定依据。 此外,有关实验数据表明ULBP1在人类肝细胞癌(HCC)中大量表达。 且NKG2D受体和ULBP1的表达与HCC炎性细胞的存在密切相关。 另有研究提示,肝切除术后的早期复发与ULBP1的表达缺失密切相关。 因此,ULBP1有望成为HCC免疫治疗的分子靶点。 CSB …
A forward genetic screen reveals novel independent regulators of ULBP1 ...
2015年11月13日 · Using a forward genetic screen in a tumor-derived human cell line, we identified several novel factors supporting expression of the NKG2D ligand ULBP1. Our results show stepwise contributions of independent pathways working at …
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