SUMO Protease, also known as Ulp, is a recombinant fragment of ULP1 (Ubl-specific protease 1) from Saccharomyces cerevisiae. It is highly specific for the SUMO protein fusion, recognizing the tertiary structure of SUMO rather than an amino acid

Ulp1 peptidase (EC 3.4.22.68, Smt3-protein conjugate proteinase, Ubl-specific protease 1, Ulp1, Ulp1 endopeptidase, Ulp1 protease) is an enzyme. [1][2][3][4][5][6] This enzyme catalyses the following chemical reaction. The enzyme from Saccharomyces cerevisiae can also recognize small ubiquitin-like modifier 1 (SUMO-1) from human.

Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SMT3 to its mature form and deconjugation of SMT3 from targeted proteins. Has an essential role in the G2/M phase of the cell cycle. Present with 377 molecules/cell in log phase SD medium.

2023年11月1日 · Ulp1 is a protease which is naturally present in yeast and specifically cleaves Ubl proteins (ubiquitin-like proteins) such as SUMO1 and Smt3 from other proteins [4]. Ulp1 is a valuable tool in molecular biology for cleaving SUMO-tags from recombinant proteins.

SUMO（小分子泛素修饰）蛋白酶1（Ulp1，来自酿酒酵母的Ubl特异性蛋白酶1）是一种高活性的半胱氨酸蛋白酶。Ulp1由于可以识别类泛素（UBL）蛋白SUMO（Smt3）的三级结构，而不是其氨基酸序列，因此具有高度特异性。

sumo 蛋白酶也被称为 ulp1，是酿酒酵母中ulp1(ubl特异性蛋白酶1)的重组片段，为一种高活性半胱氨酸蛋白酶。与普通蛋白酶识别一级结构氨基酸序列不同，sumo蛋白酶识别泛素样蛋白sumo的三级结构，可以高度特异性地将重组融合蛋白中的 sumo标签切除。

2000年5月1日 · Modification of cellular proteins by the ubiquitin-like protein SUMO is essential for nuclear processes and cell cycle progression in yeast. The Ulp1 protease catalyzes two essential functions in the SUMO pathway: (1) processing of full-length SUMO to its mature form and (2) deconjugation of SUMO from targeted proteins.

2025年2月8日 · Title: A novel mechanism for SUMO system control: regulated Ulp1 nucleolar sequestration. Data show that Esc1 and Ulp1 help retain unspliced pre-mRNAs in the nucleus, and are essential for proper nuclear basket function, which includes mRNA surveillance and regulation of SUMO protein dynamics.

The Ulp1 protease catalyzes two essential functions in the SUMO pathway: (1) processing of full-length SUMO to its mature form and (2) deconjugation of SUMO from targeted proteins. Selective reduction of the proteolytic reaction produced a covalent thiohemiacetal transition state complex between a Ulp1 C-terminal fragment and its cellular ...

Basic sequence-derived (length, molecular weight, isoelectric point) and experimentally-determined (median abundance, median absolute deviation) protein information.