Urea Sar Karkhana School & College set out for 1 January 1970. It is an institution operated by Bangladesh Chemical Industries Corporation (BCIC). It is located in the Palash Upazila of Narsingdi District and inside the Colony of Urea Sar Karkhana Ltd. Boys and girls come here from very far to study. This institute has the three disciplines of ...

Within the past ten years, a huge volume of research on the synthesis, structure-activity relationships (SAR), and anticancer activities of the urea derivatives was reported. Many aromatic urea derivatives such as N-phenyl-N'-(2-chloroethyl)ureas (CEUs) and benzoylureas (BUs) show good anticancer activity, and these compounds have mainly been ...

The SAR studies established that a terminal diaryl urea moiety with a chlorine atom at the ortho-position of the urea group was optimal for high inhibitory potency. Compound 113 exhibited potent inhibition of EGFR (IC 50 = 1 nM) and VEGFR-2 (IC 50 = 79 nM), and good antiproliferative activities on HT-29 (colorectal adeno-carcinoma), H460 (lung ...

2018年12月15日 · We now describe a baseline structure–activity relationship (SAR) for this compound series. With one exception, analogs of lead urea carboxylic acid 2 were quite polar with Log D 7.4 values ranging from −1.9 to 1.8, had high aqueous solubilities in the range of 25–100 µg/mL, and were metabolically stable.

2011年9月9日 · 2. Chemistry. The optimization of compound 1 began by modifying each side of the urea moiety with a selection of substituents to probe anti-tubercular structure activity relationships (SAR) for potentcy and selectivity. These positions are shown as R (aryl) and R (adamantyl) in Scheme 1.The synthesis of these derivatives was carried out by reacting the desired amine with the corresponding ...

2021年10月15日 · The SAR led to the identification of a novel quinoxaline urea analog 84 that reduced the levels of p-IKKβ in dose- and time-dependent studies. When compared to 13–197, analog 84 was ∼2.5-fold more potent in TNFα-induced NFκB inhibition and ∼4-fold more potent in inhibiting pancreatic cancer cell growth.

2022年9月14日 · An extensive SAR revealed the importance of the urea moiety at C20′ over bioisosteric replacement with a thiourea, carbamate or amide. Interestingly, the introduction of a sterically demanding substituent on the second ureic nitrogen significatively contributed to the anticancer potency of these derivatives. These results contradicted the ...

2017年1月5日 · 4-7 Urea, which is a naturally occurring compound, was the first organic compound which has synthesized in lab by Wohler in 1928, and played important physiological and biological roles in animal kingdom. Synthesis of urea became a remarkable step in the history of synthetic organic chemistry 8 Some of the urea derivatives are thio-urea,

2023年10月23日 · SAR of the newly synthesized urea compounds 7–11 and 13–17. Conclusion. A novel series of sulfonylurea derivatives (7–11), and aryl-urea derivatives (13–17) were evaluated as antimicrobial and anticancer agents. The current study's antimicrobial results demonstrated the efficacy of the synthesized derivatives as antimicrobial agents ...

2008年10月15日 · SAR exploration of multiple regions of a tyrosine urea template led to the identification of very potent muscarinic acetylcholine receptor antagonists such as 10b with good subtype selectivity for M(3) over M(1). The structure-activity relationships (SAR) and optimization of the tyrosine urea series are described.