药渡Cyber解析拜耳开发的USP21抑制剂BAY-805分子设计和优化详 …
usp21是泛素特异性肽酶的重要成员，在细胞凋亡、dna修复和信号转导过程中起着重要作用。usp21通过rip1的去泛素化，下调肿瘤tnf-α诱导的nf-κb激活，通过rig-i的去泛素化，下调抗病 …
USP21 Gene - GeneCards | UBP21 Protein | UBP21 Antibody
2024年12月25日 · USP21 (Ubiquitin Specific Peptidase 21) is a Protein Coding gene. Diseases associated with USP21 include Variegate Porphyria. Among its related pathways are TNF …
The emerging role of deubiquitylating enzyme USP21 as a …
2024年6月1日 · This review comprehensively summarizes the structure and biological functions of USP21 with an emphasis on its role in tumorigenesis, and elucidates the advances on the …
USP21 ubiquitin specific peptidase 21 [ Homo sapiens (human) ]
2025年2月8日 · Title: USP21 accelerates the proliferation and glycolysis of esophageal cancer cells by regulating the STAT3/FOXO1 pathway. USP21 promotes self-renewal and …
泛素特异性肽酶 21（USP21）基因 | MCE - MCE-生物活性 ...
The encoded protein cleaves ubiquitin from ubiquitinated proteins for recycling in intracellular protein degradation. The encoded protein is also able to release NEDD8, a ubiquitin-like …
USP21 deubiquitinates and stabilizes HSP90 and ENO1 to …
2024年2月4日 · In vivo and in vitro, we identified USP21 as a master regulator of CCA growth and maintenance, which directly interacted with deubiquitinates and stabilized the heat shock …
Ubiquitin-specific protease 21 stabilizes BRCA2 to control DNA
2017年7月26日 · Here, we identify the ubiquitin-specific protease USP21 as a positive regulator of BRCA2, a key mediator of DNA repair by homologous recombination. USP21 interacts with, …
Insights Into the Properties, Biological Functions, and Regulation of USP21
2022年6月29日 · Ubiquitin-specific protease 21 (USP21) is a member of the ubiquitin-specific protease family, the largest subfamily of DUBs. Although USP21 was discovered late and …
USP21 stabilizes immune checkpoint of CD276 and serves as an ...
2024年12月25日 · Our study demonstrated that USP21 was differentially expressed between normal and malignant tissues, conferring a notable value in evaluation of prognosis and …
USP21-mediated G3BP1 stabilization accelerates proliferation and ...
2024年6月21日 · Mechanistically, we found that USP21 binds to, deubiquitinates, and stabilizes the G3BP Stress Granule Assembly Factor 1 (G3BP1) protein, which is required for USP21 …