Dec 25, 2024 · USP5 (Ubiquitin Specific Peptidase 5) is a Protein Coding gene. Diseases associated with USP5 include Spermatogenic Failure 64 and Non-Syndromic X-Linked Intellectual Disability 99 . Among its related pathways are Deubiquitination and Metabolism of proteins .

May 19, 2023 · Here, we identify the ubiquitin-specific protease 5 (USP5) as a bona fide deubiquitinase for PD-1. Mechanistically, USP5 interacts with PD-1, leading to deubiquitination and stabilization of...

As one of the USPs, ubiquitin-specific proteinase 5 (USP5) is unique in that it can specifically recognize unanchored (not conjugated to target proteins) polyubiquitin and is essential for maintaining homeostasis of the monoubiquitin pool. USP5 has also been implicated in a wide variety of cellular events.

来自武汉大学的张金方教授团队在 Nature Communication 杂志（IF=17.694）上发表了题为“ ERK and USP5 govern PD-1 homeostasis via deubiquitination to modulate tumor immunotherapy ”的研究论文。 该研究采用免疫沉淀联用质谱（MS）分析、流式细胞术、去泛素化试验和多重免疫组化染色等技术，阐明了细胞外信号调节激酶（ERK）/ 泛素特异性蛋白酶5（USP5）介导的程序性细胞死亡蛋白1（PD-1）调控的分子机制，并确定了增强抗肿瘤疗效的潜在联合治疗策略。 针 …

Feb 1, 2024 · Ubiquitin specific protease 5 (USP5) is a vital deubiquitinating enzyme that regulates various physiological functions by removing ubiquitin chains from target proteins. This review provides an overview of the structural and functional characteristics of USP5.

Ubiquitin specific peptidase 5 is an enzyme that in humans is encoded by the USP5 gene. [5] [6] [7]

泛素 (见 MIM 191339) 依赖性蛋白水解是一种复杂的蛋白质代谢途径，涉及多种细胞功能，如维持染色质结构、受体功能和异常蛋白质的降解。 该过程的后期步骤涉及将降解蛋白质上的多聚泛素链分解为泛素单体。 USP5 通过连续的 exo 机制分解支链多聚泛素链，从链的近端开始 (Wilkinson 等人，1995 [PubMed 7578059]) 。 [OMIM 提供，2010 年 3 月]

Ubiquitin specific protease 5 (USP5) is a vital deubiquitinating enzyme that regulates various physiological functions by removing ubiquitin chains from target proteins. This review provides an overview of the structural and functional characteristics of USP5.

Ubiquitin specific protease 5 (USP5) is a vital deubiquitinating enzyme that regulates various physiological functions by removing ubiquitin chains from target proteins. This review provides an overview of the structural and functional characteristics of USP5.

Jun 30, 2023 · 泛素特异性肽酶5（USP5）是一种普遍表达的 去泛素化酶 （DUB）。 它已被证明参与了DNA修复、细胞凋亡、炎症和肿瘤细胞生长。 然而，USP5在结直肠癌（CRC）中的功能和分子机制仍不清楚。 在本研究中，作者研究它是如何影响结肠直肠癌细胞的生长的。 摘要部分. 作者进行了基于shRNA的高含量筛选，以确定影响 CRC细胞 生长的DUBs。 用CCK-8试验和异种移植来评估CRC细胞的生长、生存和肿瘤发生。 进行RT-qPCR、免疫印迹和免疫组化来定 …