VEGF165是一种强效的促血管生成因子，能够发挥刺激内皮细胞增殖、存活，促进血管生成，促进血管通透性增加等作用。 VEGF165在所有血管化组织中均有表达，在正常和病理性血管生成中发挥重要作用。 VEGF121与VEGF165功能相似，不同之处在于VEGF121不与细胞表面 硫酸肝素糖蛋白 (heparin sulfate proteoglycans, HSPGs)结合，大部分以游离方式存在。 且VEGF165有与 NRP-1 和 NRP-2 结合的能力，因而VEGF165还可发挥调节动脉生成、调节静脉和淋巴管内皮 …

Recombinant Human VEGF 165 is a 38.2 kDa, disulfide-linked homodimeric protein consisting of two 165 amino acid polypeptide chains. This product is shipped at ambient temperature. For storage, handling and reconstitution information, please see the lot-specific Certificate of Analysis

VEGF165是最常见且功能最强的亚型，由165个氨基酸组成，以二硫键连接形成同型二聚体，能够显著促进血管生成和提高血管通透性。 人类VEGF165的分子量约为44 kDa，并与多个动物物种具有高度同源性，为跨物种的研究和应用提供了理论支持。 此外，VEGF165是唯一能够与辅助受体NRP-1和NRP-2结合的剪接变体，这一特性进一步增强了其通过VEGFR2介导的信号传导活性，调控多种细胞反应。 1971年，Folkman提出了“肿瘤血管生成假说”，认为实体肿瘤的生长在体积 …

Gibco™ Human VEGF-165 Protein, Catalog # PHC9391. Tested in Western Blot (WB), Immunohistochemistry (IHC), ELISA (ELISA), Control (Ctrl) and Functional Assay (Functional) applications. Supplied as 100 µg purified protein.

Vascular endothelial growth factor (VEGF-165) is a heparin-binding homodimeric glycoprotein involved in embryonic vasculogenesis and angiogenesis. VEGF binds to VEGFR-1 (R1) and VEGFR-2 (R2), and activates Raf/MEK/ERK and PI3K/AKT pathways (Ferrara et al.). It plays an important role in neurogenesis both in vitro and in vivo (Storkebaum et al.).

重组人VEGF165是一种38.2kDa、二硫键连接的同源二聚体蛋白，由两条165个氨基酸的多肽链组成。 本品 重组 人VEGF165 ，以冻干粉形式提供，高活性、高纯度、低内毒素。

VEGF-A165, Human (Cat. No. Z02689) stimulates cell proliferation of HUVEC cells. The ED for this effect is typically 1-5 ng/mL. Vascular Endothelial Growth Factor (VEGF) is a potent growth and angiogenic cytokine. It stimulates proliferation and survival of endothelial cells, and promotes angiogenesis and vascular permeability.

VEGF 165, also known as Vascular Endothelial Growth Factor 165, is a protein that plays a critical role in angiogenesis, the process of forming new blood vessels from pre-existing ones. It belongs to the vascular endothelial growth factor family and is one of the most well-studied isoforms of VEGF.

VEGF (vascular endothelial growth factor) acts as a potent angiogenic factor and mitogen that stimulates proliferation, migration and formation of endothelial cells. VEGF stimulates permeabilization of blood vessels and is present in some tumors of the nervous system.

1 天前 · VEGF-A quantification in peripheral blood serum. Serum concentrations of tVEGF-A, VEGF 121, or VEGF 165, at baseline did not differ significantly between the two treatment arms (Fig. 2).The median ...

Human VEGF (165) IS is a recombinant protein optimized for use in cell culture, differentiation studies, and functional assays. Proliferation of endothelial cells. Promotion of endothelial cell migration. Chemo-attractant function, inducing migration of monocytes and osteoblasts.

VEGF 165 is the most abundant splice variant of VEGF-A (1,2). VEGF 165 is produced by a number of cells including endothelial cells, macrophages and T cells. VEGF 165 is involved in angiogenesis, vascular endothelial cell survival, growth, migration and vascular permeability (1).

血管内皮生长因子 165（vegf165）是一种强效的生长和血管生成细胞因子，属于 vegf 家族，包括 vegf-a、vegf-b、vegf-c、vegf-d、vegf-e 和 pigf。人类 vegf165 是一种丰富的糖基化细胞因子，由两条相同的 165 个氨基酸链组成。

VEGF-165 is the most abundant splice variant of VEGF-A (1,2). VEGF-165 is produced by a number of cells including endothelial cells, macrophages, and T cells. VEGF-165 is involved in angiogenesis, vascular endothelial cell survival, growth, migration, and vascular permeability (1).

2020年8月10日 · VEGF 165 (vascular endothelial growth factor-165), is a member of the VEGF family that promotes angiogenesis 1 by stimulating endothelial cell proliferation 2, 3 and migration. 4 In the central nervous system, VEGF 165 can also act as a neuroactive factor 5–7 by inducing neurogenesis 8–10 as well as neural progenitor cell (NPC) proliferation. 10...

Recombinant human VEGF 165 is a non-glycosylated homodimer, containing two 165 amino acids and having a total molecular mass of 38.2 kDa. Products are for research use only. They are not intended for human, animal, or diagnostic applications.

Vascular endothelial growth factor (VEGF or VEGFA) is a potent mediator of both angiogenesis and vasculogenesis in the fetus and adult. Humans express alternately spliced isoforms of 121, 145, 165, 183, 189, and 206 amino acids (aa) in length. VEGF165 appears to be the most abundant and potent isoform, followed by VEGF121 and VEGF189.

Vascular Endothelial Growth Factor 165 human ≥95% (SDS-PAGE), recombinant, expressed in HEK 293 cells, lyophilized powder, suitable for cell culture Synonyms: Vascular Endothelial Growth Factor 165 at Sigma-Aldrich

VEGF165，也被称为血管内皮生长因子165，是一种在血管生成中起关键作用的蛋白质，血管生成是由已有的血管形成新血管的过程。 属于血管内皮生长因子家族，是研究最充分的VEGF亚型之一。 亚科因—致力于细胞科研检测及细胞治疗领域关键试剂的研发、制造和销售，成为全球细胞制药领域创新的关键推动者。