2002年3月29日 · Dominant negative forms of Ras and Raf abolished the activation of VEGF promoter by acidic pH. These results show that acidic pH activates Ras and the ERK1/2 MAPK pathway to enhance VEGF transcription via AP-1, leading to increased VEGF production.

2025年3月22日 · VEGF-A quantification in peripheral blood serum. Serum concentrations of tVEGF-A, VEGF 121, or VEGF 165, at baseline did not differ significantly between the two treatment arms (Fig. 2).The median ...

2003年5月23日 · pH Alters the Affinity of VEGF 165 and VEGF 121 for Heparin—The increased binding of VEGF to endothelial cells and the extracellular matrix at low pH suggest that VEGF interactions with heparan sulfate are enhanced under acidic conditions.

2002年3月29日 · Overexpression of vascular endothelial growth factor (VEGF) is associated with disease progression in human glioblastomas. We recently showed that VEGF promoter activity is inversely correlated with tumor extracellular pH (pH o) …

2004年1月16日 · Vascular endothelial growth factor (VEGF) binding to endothelial cells and the extracellular matrix (ECM) increases at acidic pH (7.0-5.5). These interactions are dependent on heparan sulfate proteoglycans, but do not depend on the presence of VEGF receptors.

Vascular endothelial growth factor (VEGF) binding to endothelial cells and the extracellular matrix (ECM) increases at acidic pH (7.0–5.5). These interac-tions are dependent on heparan sulfate proteoglycans, but do not depend on the presence of VEGF receptors. Here we report that VEGF and VEGF binding to.

2003年5月23日 · Thus, the present study investigates the consequences of acidic pH on VEGF binding and activity in endothelial cell cultures. We found that the binding of VEGF165 and VEGF121 to endothelial cells increased as the extracellular pH was decreased from 7.5 to 5.5.

Physical interactions between vascular endothelial growth factor (VEGF), a central player in blood endothelial cell biology, and fibronectin, a major fibrillar protein of the extracellular matrix, are important determinants of angiogenic activity in health and disease.

2002年4月1日 · Overexpression of vascular endothelial growth factor (VEGF) is associated with disease progression in human glioblastomas. We recently showed that VEGF promoter activity is inversely correlated...

In vitro, acidic pH considerably reduced VEGF-mediated endothelial cell responses, suggesting that in acidic conditions endothelial cells prosper independently of VEGF. Accordingly, we found that low pH values significantly reduced the expression of VEGFR-2 by EC.