2021年5月17日 · 囊泡谷氨酸转运体（vesicular glutamate transporters， VGLUTs）能特异地装载谷氨酸进入突触囊泡并促进释放，它包括3个成员，其中VGLUT1和VGLUT2是谷氨酸能神经元和它们轴突末端高度特异的标志，同时VGLUT1标志着皮质-皮质投射，VGLUT2标志着丘脑-皮层投射。 而VGLUT3则会出现在胆碱能中间神经元、5-羟色胺能神经元、海马和皮层中GABA能中间神经元中。 VGLUTs的异常会导致兴奋性神经递质谷氨酸的异常，从而诱发多种神经系统疾病。 囊 …

Glutamate transporters are a family of neurotransmitter transporter proteins that move glutamate – the principal excitatory neurotransmitter – across a membrane. The family of glutamate transporters is composed of two primary subclasses: the excitatory amino acid transporter (EAAT) family and vesicular glutamate transporter (VGLUT) family.

VGLUT1 and VGLUT2, the two major isoforms of VGLUT in the brain, are expressed in two functionally-distinct subpopulations of glutamatergic synapses that differ in their probability of transmitter release and capacity for synaptic plasticity (Du et al. 2020) and Fig. 5.

vglut家族包含3个成员，vglut1 (也被称为bnpi)，vglut2 (也被称为dnip) 和vglut3 (见表1)。所有的谷氨酸转运蛋白(eaats and vgluts)是多次跨膜蛋白，拥有多达12个跨膜结构域。

Here we report that the vesicular-glutamate transporter 2 (VGLUT2) functions as a specific marker gene for subicular burst-firing neurons, and demonstrate that VGLUT2-Cre mice allow for Channelrhodopsin-2 (ChR2)-assisted connectivity analysis.

与VGLUT 1一样，囊泡型谷氨酸转运蛋白2（VGLUT 2）对于谷氨酸的吸收和储存既是必要的也是充分的，因此是谷氨酸表型的唯1决定因素。 VGLUT 1和VGLUT 2这两种VGLUT都不同于质膜转运蛋白，因为它们是由跨囊泡膜的质子电化学梯度驱动的。 ( VGLUT 1和VGLUT 2呈现互补表达模式。 总而言之，它们是目前 谷氨酸能神经末梢 和 谷氨酸能突触 的zui好标记物) 这里不得不提一下这个比较厉害的角色——VGLUT 2 - 135 403，来自德国SySy，纵横 Nature, Cell，超能打！ …

2021年6月2日 · Here we show that the subpopulation of midbrain dopaminergic neurons that express the vesicular glutamate transporter 2 (VGLUT2) are more resilient to rotenone-induced neurodegeneration. Rotenone also upregulates VGLUT2 more broadly in the midbrain, suggesting that VGLUT2 expression generally confers increased resilience to rotenone.

2023年5月11日 · In the mammalian central nervous systems, three vesicular glutamate transporters (VGLUT1, VGLUT2 and VGLUT3) are responsible for filling the synaptic vesicles of excitatory neurons with glutamate...

The highly homologous protein VGLUT2, also initially characterized as a phosphate transporter and named differentiation-associated Na +-dependent inorganic phosphate transporter (DNPi), has a nearly complementary pattern of expression with one of the two proteins present in all established glutamatergic neurons. In general, VGLUT1 predominates ...

2020年5月30日 · VGLUT1 and VGLUT2 are expressed in distinct and complementary subsets of neurons in the CNS that display differences in release probability [36, 39]. VGLUT1 is the most abundant subtype in the CNS [47].