2014年2月27日 · Classic vulvar intraepithelial neoplasia, abbreviated classic VIN, is a pre-neoplastic lesion of the vulva strongly associated with the human papilloma virus. It is also …

The histopathologic definition of dVIN is basal atypia combined with negative or nonblock-positive p16 and basal overexpressed, aberrant negative, or wild-type p53. The most common pattern …

2023年9月19日 · Immunohistochemistry by p16 INK4a and p53 is highly recommended for optimal categorization into HPV-associated and HPV-independent VIN, which is of utmost …

Immunohistochemistry stains: uVIN/HSIL is p16 positive, and dVIN is p53 positive. Warty lesions in postmenopausal women should undergo biopsy, particularly if they do not resolve with …

2021年1月6日 · High grade squamous intraepithelial lesion (HSIL): vulvar intraepithelial neoplasia of usual type (u-VIN), high grade vulvar intraepithelial neoplasia, vulvar intraepithelial …

In contrast, differentiated or simplex-type VIN is consistently negative for p16 and the majority of the cases harbour TP53 mutations, correlating with p53 positivity by immunohistochemistry. …

This study was undertaken to examine the expression of p16 and p53 in vulvar intraepithelial neoplasia (VIN) and squamous cell carcinoma (SCC) of the vulva. We also analyzed the …

Since uVIN is driven by high-risk human papilloma virus infections, p16 immunohistochemistry is diffusely positive in these lesions and is characterized with a high Ki-67 proliferation index. In …

Simplex VIN is characterized by atypia of the basal layer with high degree of cellular differentiation and shows negative staining for p16(INK4a) and frequent positivity for p53. Simplex VIN is …

2023年12月6日 · What is vulvar intraepithelial neoplasia (VIN)? Vulvar intraepithelial neoplasia (VIN) involves having precancerous skin cells on your vulva. But this part’s important — VIN …