VLA-4, specifically the alpha subunit, is crucial for the localization and circulation of progenitor cells. In mice, it has been shown that injected anti-alpha antibodies result in an increase in progenitor cell circulation and duration. [1] .

迟现抗原-4 英文名称 very late appearing antigen-4;VLA-4 定 义 α4β1(CD49d/CD29)整合素。分布于胸腺细胞、单核细胞、B细胞、T细胞、NK细胞，配体为纤连蛋白和VCAM-1。 应用学科 免疫学（一级学科），免疫系统（二级学科），免疫分子（三级学科）

VLA-4 integrin is a heterodimeric molecule, consisting of an α4 and a β1 chain, expressed on most leukocytes and is involved in leukocyte trafficking into a variety of organs. Monoclonal antibodies specific for the α4 chain have proven to be effective in suppressing autoimmune disease in several animal models, and very early results from ...

VLA-4 (very late antigen 4, 3 α 4 β 1-integrin, CD49d/CD29) plays a major role in the regulation of immune cell recruitment to inflamed endothelia and sites of inflammation. It participates in antigen presenting cell-lymphocyte interactions, retention and mobilization of immature progenitors in the bone marrow ( 1 , 2 ), cancer cell ...

2024年8月14日 · We report that the BCR is also able to effectively inside–out activate the VLA-4 integrin in circulating CD49d-expressing CLL cells through an autonomous antigen-independent BCR signaling.

2023年6月9日 · 有研究表明，活化γδ T细胞高表达VLA-4，并且VLA-4的表达与静止γδ T细胞的活化增殖相关，说明VLA-4有望作为一种成像标志物以监测γδ T 细胞免疫治疗 期间细胞激活、迁移和定位。 华中科技大学同济医学院附属协和医院 兰晓莉 教授、盖永康副教授团队采用永新动物PET/SPECT/CT一体机证实了VLA-4靶向探针68Ga-LLP2A在体内无创可视化γδ T细胞的肿瘤归巢和监测治疗疗效的可行性。 文章在线发表在European Journal of Nuclear Medicine and …

vla-4是粘附受体整联蛋白超家族中的细胞表面异二聚体。 抗VLA-4抗体抑制细胞溶解性T细胞活性，且其抑制活性针对效应T细胞而不是其靶标。 因此，尽管其他VLA受体似乎介导细胞-基质相互作用，但VLA-4可能具有细胞-细胞粘附功能。

2014年6月14日 · Shalapour S,Hof J,Kirschner-Schwabe R,et al.High VLA-4 expression is associated with adverse outcome and distinct gene expression changes in childhood B-cell precursor acute lymphoblastic leukemia at first relapse[J].Haematologica,2011,96:1627-1635.

2025年2月6日 · We evaluate VLA-4 (integrin α4β1) as a potential target for RPT in solid tumors using radiolabeled copper-64 ([64Cu]Cu-) and copper-67 ([67Cu]Cu-CB-TE1A1P-PEG4-LLP2A) LLP2A, a peptidomimetic ligand of VLA-4, for preclinical imaging and RPT testing.

VLA-4 (very late activation antigen 4, CD49d/CD29) is a cell-surface molecule that is expressed on monocytes, eosinophils, basophils and lymphocytes [34,35]. VLA-4 is involved in leukocyte adhesion to activated endothelial cells with subsequent migration from the vasculature into pulmonary tissue and the alveolar compartment during inflammatory ...