2006年4月20日 · In this article, we demonstrate that an increase in ADRP promotes the storage of triglycerides in cytosolic lipid droplets and inhibit their secretion as VLDL. Conversely, a …

VLDL stimulation of FAO hepatoma cells infected with Ad-HL significantly increased ADRP mRNA levels in a VLDL concentration-dependent manner (Fig. 4A). HL hydrolysis of VLDL also …

2006年1月1日 · Cells treated with VLDL contained three times the amount of ADRP as cells incubated without lipoproteins, whereas incubation of the cells with AcLDL increased the …

Addition of triacsin C, a potent inhibitor of acyl-CoA synthase, for 6 h decreased the amount of TG in VLDL-induced foam cells and oleic acid-treated liver cells; it decreased the amount of ADRP …

An increase in ADRP prevents the formation of VLDL by diverting fatty acids from the VLDL assembly pathway into cytosolic triglycerides, whereas a decrease of the protein increases the …

我们还提出,脂滴有可能直接为VLDL的脂化提供脂肪来源.Cideb和ADRP有可能通过调节脂滴中的脂肪向其他脂滴或者VLDL的流动,转运来调控脂滴的大小和VLDL的脂化成熟程度.

特异性的沉默肝脏ADRP的表达能够减少肝脏脂肪（TAG）的积累，增强VLDL-TG的分泌，并且增加Golgi体中成熟的、TAG含量丰富的VLDL的积累。 过表达ADRP有相反的效果。 并 …

Extended further, VLDL stimulation of HL-expressing HUVECs and FAO hepatoma cells increased mRNA expression of canonical PPARδ target genes, including adipocyte …

Treatment of WT macrophages with VLDL results in triglyceride accumulation and the induction of adipose differentiation-related protein (ADRP). Remarkably, disruption of the PPARδ gene in …

An increase in ADRP prevents the formation of VLDL by diverting fatty acids from the VLDL assembly pathway into cytosolic triglycerides, whereas a decrease of the protein increases the …