
Structural studies of the eIF4E–VPg complex reveal a direct ... - PNAS
2019年11月12日 · We demonstrated that VPg binds the cap-binding site of eIF4E and forms trimeric complexes with eIF4E and eIF4G; furthermore, we demonstrated that VPg–RNA …
Norovirus Translation Requires an Interaction between
2014年8月1日 · Mutational analyses indicated that the C-terminal region of VPg is important for the VPg-eIF4G interaction; viruses with mutations that alter or disrupt this interaction are …
Norovirus translation requires an interaction between the C ... - PubMed
2014年8月1日 · Mutational analyses indicated that the C-terminal region of VPg is important for the VPg-eIF4G interaction; viruses with mutations that alter or disrupt this interaction are …
A Conserved Interaction between a C-Terminal Motif in Norovirus VPg …
2016年1月6日 · Fine mutagenic mapping suggests that the MNV VPg C terminus may interact with eIF4G in a helical conformation. NMR spectroscopy was used to define the VPg binding …
A Conserved Interaction between a C-Terminal Motif in Norovirus VPg …
The functional significance of the VPg-eIF4G interaction was shown by the ability of fusion proteins containing the C-terminal peptide of MNV VPg to inhibit in vitro translation of …
Structural studies of the eIF4E-VPg complex reveal a direct ... - PubMed
2019年11月26日 · The potyvirus-derived viral genome-linked protein (VPg) is covalently bound to the 5' end of viral genomic RNA (gRNA) and associates with host eIF4E for successful …
To dissect these possibilities, we resolved the structure of VPg, revealing a previously unknown 3-dimensional (3D) fold, and characterized the VPg–eIF4E complex using NMR and biophysical …
Norovirus Translation Requires an Interaction between the C …
This approach revealed that VPg binds directly to the eIF4F complex, with a high affinity interaction occurring between VPg and eIF4G. Mutational analyses indicated that the C …
Potyvirus Genome-linked Protein, VPg, Directly Affects Wheat …
2008年1月18日 · Potyvirus genome linked protein, VPg, interacts with translation initiation factors eIF4E and eIFiso4E, but its role in protein synthesis has not been elucidated. We show that …
Structural studies of the eIF4E–VPg complex reveal a direct …
We demonstrated that VPg binds the cap-binding site of eIF4E and forms trimeric complexes with eIF4E and eIF4G; furthermore, we demonstrated that VPg–RNA conjugates directly bind …