Valinomycin is a naturally occurring dodecadepsipeptide used in the transport of potassium and as an antibiotic. Valinomycin is obtained from the cells of several Streptomyces species, S. fulvissimus being a notable one.

Valinomycin is a nonribosomal peptide that was discovered from Streptomyces in 1955. Over the past more than six decades, it has received continuous attention due to its special chemical structure and broad biological activities.

Valinomycin is a natural antibiotic from Streptomyces and is a depsipeptide, i.e. it consists of alternating hydroxy and amino acids. The ions lose their water of hydration when they bind to the ionophore.

2018年6月12日 · (From Merck Index, 11th ed) Valinomycin is a potassium selective ionophore and is commonly used as a tool in biochemical studies. The next evolution of DrugBank is here. Designed for scientists, driven by AI, and powered by real-time insights. This is …

Valinomycin is a twelve-membered cyclodepsipeptide composed of three repeating D-alpha-hydroxyisovaleryl-D-valyl-L-lactoyl-L-valyl units joined in sequence. An antibiotic found in several Streptomyces strains.

Valinomycin selectively transfers alkali metal ions via biological and synthetic membranes. The formation of a metal ion-peptide complex contributes to this ion-transporting. Valinomycin can create stable complexes with potassium, rubidium, and cesium (K +, Rb +, and Cs +) .

2015年3月4日 · Valinomycin (Vln) is a small molecule, natural antibiotic, K + selective carrier, that has been studied and used in research for over half of a century (Ovchinnikov et al. 1974). Simple addition of this cyclic peptide to the red blood cells or into liposomal suspension makes biomembranes permeable toward K + ions.