2024年12月25日 · VAPB (VAMP Associated Protein B And C) is a Protein Coding gene. Diseases associated with VAPB include Amyotrophic Lateral Sclerosis 8 and Spinal Muscular Atrophy, Late-Onset, Finkel Type. Among its related pathways are …

Vesicle-associated membrane protein-associated protein B/C is a protein that in humans is encoded by the VAPB gene. [5] [6] The VAPB gene is found on the 20th human chromosome. Together with VAPA, it forms the VAP protein family.

2020年12月17日 · Vesicle-associated membrane protein B (VAPB) is an ER-residing protein that interacts with protein tyrosine phosphatase-interacting protein-51 (PTPIP51) in the OMM .

2023年8月1日 · VAPB, an ER-anchored protein that mediates tethers between ER and membranes of other organelles, was identified as a direct interacting partner of IRS-1. VAPB mainly binds active IRS-1 because...

2024年10月10日 · VAMP-associated protein (VAP) is a type IV integral transmembrane protein at the endoplasmic reticulum (ER). Mutations in human VAPB/ALS8 are associated with amyotrophic lateral sclerosis...

Vesicle-associated membrane protein (VAMP)-associated proteins (VAPs) are ubiquitous ER-resident tail-anchored membrane proteins in eukaryotic cells. Their N-terminal major sperm protein (MSP) domain faces the cytosol and allows them to …

VAPB promotes breast tumor growth by modulation of Akt activity. The binding residues have been successfully mapped out on both NS5A and VAPB, thus allowing the construct of the complex structure. The mutation in VAPB that causes amyotrophic lateral sclerosis also causes the block of transport of nucleoporins and emerin to the nuclear envelope.

In this review, we summarize and compare the recent interactome studies described for VAPs, including in silico and proximity labeling methods. Collectively, the interaction repertoire of VAPs is very diverse and highlights the complexity of interactions mediated by the different FFAT motifs to …

2024年3月5日 · Clinical resource with information about VAPB, Adult-onset proximal spinal muscular atrophy, autosomal dominant, Amyotrophic lateral sclerosis type 8, and available tests. There are links to practice guidelines and authoritative resources like GeneReviews, PubMed, MedlinePlus, PharmGKB and clinicaltrials.gov.

2024年1月29日 · 该研究结合三维电子显微镜与模型细胞器系，囊泡相关膜蛋白（VAMP）相关蛋白B（VAPB）的高速分子跟踪，以绘制ERMCSs的结构和融合现象。 研究人员发现了VAPB接触位点内与内质网膜弯曲率相关并经历快速重构的动态子域。 VAPB分子在几秒钟内进入和离开ERMCSs，尽管接触位点本身在更长的时间尺度内保持稳定。 这种亚稳态允许ERMCSs通过生理环境的变化进行重塑，以适应细胞的代谢需求。 VAPB中肌萎缩侧索硬化症相关突变扰乱了这 …