2021年12月22日 · Our findings identify tRNA deregulation as a critical adaptation in the pathogenesis of T-ALL and provide a molecular basis for the use of dietary approaches to target tRNA biogenesis in blood...

2024年6月7日 · Here we show that valine aminoacyl-tRNA synthetase (VARS) is a key player in the codon-biased translation reprogramming induced by resistance to targeted (MAPK) therapy in melanoma.

The VARS gene encodes cytoplasmic valyl-tRNA synthetase (ValRS), an enzyme that is essential during eukaryotic translation. cDNA analysis on patient derived fibroblasts revealed that the splice site acceptor variant allele led to nonsense mediated decay, thus resulting in a null allele.

2019年2月12日 · VARS encodes the only known valine cytoplasmic-localized aminoacyl-tRNA synthetase. Here, we report seven patients from five unrelated families with five different biallelic missense variants...

本研究旨在探究在MM中异常表达的氨基酸代谢关键因子ARS通过调控氨基酸代谢影响MM生长的分子机制。 对应基因编号合并基因表达综合 (Gene Expression Omnibus，GEO)数据库中基因表达谱 GSE5900 数据集及 GSE2658 数据集数据，对 ARS 家族基因表达数据进行标准化处理。 采用GSEA_4.2.0软件分析健康供者 (healthy donor，HD)与MM患者基因富集的差异。 采用GraphPad Prism 7绘制基因热图并进行数据分析。 采用Kaplan-Meier及Cox回归模型分别对 ARS 家族基 …

2024年10月15日 · 本研究旨在探究在MM中异常表达的氨基酸代谢关键因子ARS通过调控氨基酸代谢影响MM生长的分子机制。 对应基因编号合并基因表达综合 (Gene Expression Omnibus，GEO)数据库中基因表达谱GSE5900数据集及GSE2658数据集数据，对 ARS 家族基因表达数据进行标准化处理。 采用GSEA_4.2.0软件分析健康供者 (healthy donor，HD)与MM患者基因富集的差异。 采用GraphPad Prism 7绘制基因热图并进行数据分析。 采用Kaplan-Meier …

Here we show that valine aminoacyl-tRNA synthetase (VARS) is a key player in the codon-biased translation reprogramming induced by resistance to targeted (MAPK) therapy in melanoma. The proteome rewiring in patient-derived MAPK therapy-resistant melanoma is biased towards the usage of valine and coincides with the upregulation of valine cognate ...

VARS mutations produce severe neurological implications, illustrating the essential nature of this gene in the development and proper functioning of the nervous system. This study expands the molecular and clinical phenotyping of patients with bi-allelic VARS mutations.

The VARS gene encodes the cytoplasmic aminoacyl-tRNA synthetase for valine (summary by Friedman et al., 2019). Cloning and Expression Hsieh et al. (1991) identified the G7a gene, encoding human valyl-tRNA synthetase, within the class III region of the major histocompatibility complex (MHC).

2019年2月12日 · Here we report an allelic series consisting of seven novel and two previously reported biallelic variants in valyl-tRNA synthetase (VARS) in ten patients with a developmental encephalopathy with...