Aggrecan and versican: two brothers close or apart
2022年5月10日 · Aggrecan (Acan) and versican (Vcan) are large chondroitin sulfate proteoglycans of the extracellular matrix. They share the same structural domains at both N- …
Child abuse associates with increased recruitment of ... - Nature
2021年11月19日 · The main canonical components of PNNs, namely aggrecan (ACAN), neurocan (NCAN), versican (VCAN), phosphacan (PTPRZ1), brevican (BCAN), and tenascin …
Perineuronal Nets in Spinal Motoneurones: Chondroitin Sulphate ...
2018年4月12日 · Perineuronal nets (PNNs) are extracellular matrix structures surrounding neuronal sub-populations throughout the central nervous system, regulating plasticity. …
VCAN Gene - GeneCards | CSPG2 Protein | CSPG2 Antibody
2024年12月25日 · VCAN (Versican) is a Protein Coding gene. Diseases associated with VCAN include Wagner Vitreoretinopathy and Wagner Disease. Among its related pathways are …
Modulation of stress-, pain-, and alcohol-related behaviors by ...
Perineuronal nets (PNNs) are a condensed, mesh-like form of ECM composed of hyaluronan, chondroitin sulfate proteoglycans (CSPGs: aggrecan, brevican, neurocan, versican, and …
Circulation：阜外医院聂宇教授课题组与胡盛寿院士团队合作鉴定 …
2023年11月4日 · 该研究通过单细胞 RNA 测序和液相色谱 - 质谱联用分析，鉴定了心脏中一种可以促进心肌细胞增殖的调控因子 versican，并进一步揭示了 versican 在促进内源性心肌细胞增 …
脑细胞外基质：神经和精神疾病的一个即将到来的目标,European …
人类 Fras1 的突变是造成弗雷泽综合征的原因，该综合征偶尔会在患者中观察到脑畸形和精神障碍。在Fras1缺陷小鼠的皮层和皮层下区域发现 PNN 的 ECM 杂乱无章，表现出许多行为缺陷， …
2020年10月19日 · Childhood and adolescence are marked by the protracted formation of perineuronal nets (PNNs), which are essential in orchestrating the closure of developmental …
Under the ECM Dome: The Physiological Role of the Perinodal
2019年11月24日 · Two forms of condensed hyaluronan-based ECM are found along the axon: the axon initial segment (AIS) domain of the perineuronal net (PNN) and the node of Ranvier …
Proteoglycans in brain development and pathogenesis
2018年3月7日 · CSPGs also are important in synapse stabilization and maturation, mainly as components of perineuronal nets (PNNs), the specialized matrices that surround neurons and …