2022年7月1日 · These studies revealed a novel active neuroendocrine regulatory polypeptide, VGF nerve growth factor inducible (VGF). VGF is an NGF-inducible transcript in PC12 cells, and this non-acronymic name is accepted because the identified clone was selected from plate “V” of a PC12 cDNA library [7].

The neurosecretory protein VGF (non-acronymic, also known as secretogranin VII), belongs to the granin family of neuropeptides, distinctively composed of acidic secretory proteins. 1 VGF was first identified as a nerve growth factor (NGF)-response gene by cloning of the nervous system-specific mRNA, VGF8a, from PC12 cells treated with NGF. 2 ...

1996年9月1日 · vgf is an inducible gene, highly sensitive to nerve growth factor (NGF) and remarkably upregulated in the “early-delayed” phase of response (within a few hours). It encodes a 617-amino acid polypeptide (VGF protein) bearing no significant homology with known sequences and restricted to certain peptide/amine-producing endocrine cells, and ...

在大脑中，vgf 以多种功能性 vgf 衍生肽的形式存在。全长人 vgf1-615 在受调节的分泌途径中通过激素原转化酶和其他蛋白酶进行蛋白水解加工，产生至少 12 种活性 vgf 衍生肽。

Neuroendocrine regulatory polypeptide VGF (nerve growth factor inducible) was firstly found in the rapid induction of nerve growth factor on PC12 cells. It was selectively distributed in neurons and many neuroendocrine tissues. This paper reviewed the latest literatures on the gene structure, transc …

2011年12月1日 · The vgf gene (non-acronymic) is induced in vivo by neurotrophins including Nerve Growth Factor (NGF), Brain Derived Growth Factor (BDNF) and Glial Derived Growth

Both the mRNA and encoded approximately 68-kDa protein (VGF) are selectively synthesized in neuroendocrine and neuronal cells. The predicted VGF sequence is rich in paired basic amino acid residues that are potential sites for proteolytic processing, and VGF undergoes regulated release from dense core secretory vesicles.

2015年2月1日 · VGF peptides have been associated with a number of neuroendocrine roles, and in this review, we aim to describe these roles to highlight the importance of VGF as therapeutic target for a number of disorders, particularly those associated with energy metabolism, pain, reproduction, and cognition.

神经内分泌调节多肽VGF（nerve growth factor inducible）最早发现于神经生长因子对PC12细胞的快速诱导作用。它选择性地分布在神经元和许多神经内分泌组织中。本文回顾了有关VGF基因结构、转录调控、蛋白质加工、分布和潜在受体的最新文献。

2024年12月25日 · VGF (VGF Nerve Growth Factor Inducible) is a Protein Coding gene. Diseases associated with VGF include Vaccinia and Pheochromocytoma . Among its related pathways are Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) and Signaling by NTRKs .