2021年3月4日 · Knockdown resistance (kdr) resulting from the Voltage-Gated Sodium Channel (VGSC) is one of the mechanisms of resistance in pyrethroid group insecticide....

2022年11月1日 · VGSC-DB is the first open-source database for VGSCs, which provides open access to 6055 data records, including 3396 compounds from 173 references toward nine subtypes of Na v s (Na v 1.1 ~ Na v 1.9).

2022年1月12日 · A recurring target-site mutation identified in various pests and disease vectors alters the voltage gated sodium channel (vgsc) gene (often referred to as knockdown resistance or kdr) to confer...

2016年7月21日 · Pyrethroid resistance in insects is conferred by mutations in the voltage-gated sodium channel (VGSC) gene and increased activity of detoxification enzymes, such as cytochrome P450s 8.

2021年9月26日 · Voltage-gated sodium channel (VGSC) mutation-mediated knock-down resistance (kdr) has developed in many A. sinensis populations because of intensive and long-term use of pyrethroids. Our previous study showed that multiple mutations at position 1014 of the VGSC were heterogeneously distributed in A. sinensis populations across Sichuan, China.

2023年6月3日 · Knockdown resistance (kdr) caused by point mutations in the voltage-gated sodium channel (VGSC) gene is a primary mechanism of pyrethroid resistance. In this study, we investigated the kdr mutations of Ae. albopictus in Shanghai and evaluated the trend in …

2019年7月1日 · VGSCs (or Navs) are heteromeric transmembrane proteins that are activated in response to membrane depolarization and have a fundamental role in the generation and propagation of action potentials in neurons and other electrically excitable cells via control of the flow of Na+ ions through cell membranes.

2024年12月30日 · VGSC is a highly conserved protein with Ion channel conserved structural domains of transmembrane proteins. qPCR showed that the VGSC gene was highly expressed in the epidermis of 2nd instar larvae, and its expression level was low in other tissues, such as the foregut and Malpighian tubules.

Resistance to these chemicals has been reported to be associated with mutations in the voltage-gated sodium channel (VGSC) gene of the Rhipicephalus microplus. This study investigates R. microplus resistance to pyrethroids in Guangxi region of China, marking one of the first research efforts in this area.

2019年11月18日 · In this study, we designed biotinylated oligonucleotide probes from CDSs of VGSC of Asian tiger mosquito, Aedes albopictus. The probe set effectively concentrated (>80,000-fold) all targeted regions of gene VGSC from pooled barcoded Illumina libraries each constructed from individual A. albopictus gDNAs.

2023年6月2日 · Knockdown resistance (kdr) caused by point mutations in the voltage-gated sodium channel (VGSC) gene is a primary mechanism of pyrethroid resistance. In this study, we investigated the kdr mutations of Ae. albopictus in Shanghai and evaluated the trend in …

The pore-forming subunits (α subunits) of voltage-gated sodium channels (VGSC) are encoded in humans by a family of nine highly conserved genes. Among them, SCN1A, SCN2A, SCN3A, and SCN8A are primarily expressed in the central nervous system.

2023年6月2日 · Knockdown resistance (kdr) caused by point mutations in the voltage-gated sodium channel (VGSC) gene is a primary mechanism of pyrethroid resistance. In this study, we investigated the kdr mutations of Ae .

2019年3月28日 · RNA interference (RNAi) is a valuable reverse genetics tool used in functional genomics, but recently, it has also shown promise as a novel agent that could be used to control agricultural insect...

2019年11月18日 · In this study, we designed biotinylated oligonucleotide probes from CDSs of VGSC of Asian tiger mosquito, Aedes albopictus. The probe set effectively concentrated (>80,000-fold) all targeted regions of gene VGSC from pooled barcoded Illumina libraries each constructed from individual A. albopictus gDNAs.

2024年11月1日 · In the present study, we examined the presence of resistance mutations in the VGSC gene, encoding the target of pyrethroids, in the V. destructor population collected from the Kayseri and Sivas provinces of Central Anatolia Region of Türkiye. A total of 200 V. destructor samples were collected from 20 apiaries in two provinces throughout 2023.

In this study, we designed biotinylated oligonucleotide probes from CDSs of VGSC of Asian tiger mosquito, Aedes albopictus. The probe set effectively concentrated (>80,000-fold) all targeted regions of gene VGSC from pooled barcoded Illumina libraries each constructed from individual A. albopictus gDNAs.

2024年7月17日 · Resistance to these chemicals has been reported to be associated with mutations in the voltage-gated sodium channel (VGSC) gene of the Rhipicephalus microplus. This study investigates R. microplus resistance to pyrethroids in Guangxi region of China, marking one of the first research efforts in this area.

2024年8月14日 · VGSC 是一种完整的跨膜蛋白，由约 2,000 个氨基酸残基组成，存在于神经元、肌细胞、内分泌细胞和卵巢细胞中，参与可兴奋细胞动作电位的启动和传播。 在本研究中，通过cDNA末端快速扩增 (RACE)鉴定了该蛋白的cDNA序列，该序列包含一个6,261 bp的开放阅读框，编码2,086个氨基酸的蛋白质。 该蛋白的分子量预计为236 kDa，理论等电点为5.21。 基于鳞翅目昆虫构建的系统发育树表明， 的 VGSC 与 的亲缘关系最密切。 VGSC是一种高度保守的蛋 …

2024年7月17日 · Resistance to these chemicals has been reported to be associated with mutations in the voltage-gated sodium channel (VGSC) gene of the Rhipicephalus microplus. This study investigates R. microplus resistance to pyrethroids in Guangxi region of China, marking one of the first research efforts in this area.