2020年2月1日 · Simplified monomeric monoclonal antibodies consisting of a single-domain VHH, derived from camelid heavy-chain only antibodies, fused with the Fc domain of either IgG (VHH-IgG) or IgA (VHH-IgA) antibodies, are promising therapeutic proteins.

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Here, we report the characterization of a VHH-derived IgG-like bi- and trispecific antibody platform that essentially relies on the replacement of the VH and VL regions of a conventional antibody by two independently functioning VHH domains.

2022年3月30日 · Here, we propose a gene transfer strategy based on BBB‐crossing adeno‐associated virus (AAV)‐based vectors to deliver VHH directly into the CNS. As a proof‐of‐concept, we explored the potential of AAV‐delivered VHH to inhibit BACE1, a well‐characterized target in Alzheimer’s disease.

Simplified monomeric monoclonal antibodies consisting of a single-domain VHH, derived from camelid heavy-chain only antibodies, fused with the Fc domain of either IgG (VHH-IgG) or IgA (VHH-IgA) antibodies, are promising therapeutic proteins. These simplified single-gene encoded antibodies are much e …

2020年8月11日 · VHH antibodies are the isolated VHH domains of heavy-chain only IgG2 and IgG3 antibodies produced by camelid species, such as alpaca, llama, and camel. These proteins consist of framework regions and three highly variable loops; H1, H2 and H3.

体布拉格光栅(VBG，VHG)，可被置于激光共振腔内用以对激光器波长锁定（中心波长精度为0.1-0.5nm ） 、横模纵模选取及控制、激光线宽压窄（低至20pm ）及提升激光器工作温度范围。

Implementation of the Berndt-Hall-Hall-Hausman (BHHH) algorithm. - Pascalheid/BHHH

In order to find our code including examples and tests please follow the path src/algorithms. For the documentation as a pdf and html please follow bld/src/documentation. Implementation of the Berndt-Hall-Hall-Hausman (BHHH) algorithm. - Pascalheid/BHHH.

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