scFv和VHH都被用来结合和中和血管内皮生长因子受体2（VEGFR-2）。 抑制细胞因子和趋化因子是癌症和自身免疫性疾病的潜在治疗选择。VHH和scFv已被用于阻断几种炎症和免疫调节细胞因子，用于治疗类风湿关节炎、慢性炎症、自身免疫性炎症性疾病、癌症和中风。

像IgG-VHH和VHH-VHH-Fc这些最简单的双抗format却还在临床早期。 究其原因，一方面VHH早期的专利严重限制了其发展速度，直到2014-2016年，相关专利才逐渐放开；另一方面，免费的东西未必人人都肯吃啊。

2017年8月21日 · We identified 25 distinct VHH families binding trimeric Env, of which 6 neutralized heterologous primary isolates of various HIV-1 subtypes in a standardized in vitro neutralization assay.

Heavy-chain variable region antigen-binding fragment (VHH) antibodies targeting C5 and human serum albumin (HSA) were isolated from llama immune-based libraries and humanized. Gefurulimab comprises an N-terminal albumin-binding VHH connected to a C-terminal C5-binding VHH via a flexible linker.

图5 vhh氨基酸序列的系统进化树图 项目总结 以cDNA为模板，经PCR扩增得到了VHH抗体基因片段，并分别在其5’端和3’端引入了SacI和SpeI酶切位点。

2024年6月3日 · vhh域的位置灵活性可能取决于目标抗原以及当vhh置于另一个蛋白域的c-末端时抗原结合环的可及性。 Alvarez-Cienfuegos等人最近描述了一个例子，即生产称为trimergebodies的三聚体分子。

2007年7月31日 · Here we describe the development of specific, high affinity Camelid antibody fragments (VHH) derived from immune libraries for purification and depletion of the bulk protein HSA and IgG from human serum and plasma for therapeutic and research purposes.

Both, VHH-5 and VHH-28, have a long CDR3 region that folds over to partially mask the face of the VH domain that would be involved in contacts with the VL domain in a typical Fab fragment. The...

Structural characterization of CD8ɑ:VHH5 complex and flow cytometry analysis in PBMCs. A Superposition of the complexes of VHH5 (gold) and RED8 Fab (gray) with CD8ɑ (dark blue) showed that the...

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