Simplified monomeric monoclonal antibodies consisting of a single-domain VHH, derived from camelid heavy-chain only antibodies, fused with the Fc domain of either IgG (VHH-IgG) or IgA …

2022年3月9日 · Here, we evaluated in vivo efficacy and safety of the lead trispecific VHH-Fc, ABS-VIR-001. Importantly, our data showed that ABS-VIR-001 treatment prevented SARS …

With around 15 kD molecular weight, VHHs are considered the smallest antigen-binding fragments. Based on their unique properties, VHHs have broad application prospects such as …

Nanobodies® (VHHs) provide powerful tools in therapeutic and biotechnological applications. Nevertheless, for some applications, bivalent antibodies perform much better, and for this, an …

We demonstrated that modification of neutralizing VHHs with a human immunoglobulin G (IgG)1 Fc (fragment crystallizable) fragment (fusionbody, VHH-Fc) significantly increased the …

2016年7月21日 · Engineered conventional-like antibodies, by fusion of the Fc part of immunoglobulins to antigen-specific heavy-chain only VHH fragments, might be applied to …

2020年10月20日 · These tri-specific VHH-Fcs are not only extremely potent in SARS-CoV-2 S1 RBD binding and S/ACE2 blocking, but also potently inhibited the infection of human target …

2017年11月21日 · A bispecific heavy chain antibody can be generated simply by linking two tandem VHH domains (blue) to the hinge and Fc domains of human IgG. Both specificities are …

2024年5月3日 · To combat SARS-CoV-2 antigenic escape, we developed a rapid, high-throughput pipeline to discover monospecific VHH antibodies and iteratively develop VHH-Fc …

2024年8月22日 · Similarly, the VHH can gain functionality: “I think it is pretty straightforward to add the Fc back to the VHH scaffold,” says Yi Shi, Founding Director, Center for Protein …