VirB is a key regulator of genes located on the large virulence plasmid (pINV) in the bacterial pathogen Shigella flexneri. VirB is unusual, as it is not related to other transcriptional regulators; instead, it belongs to a family of proteins that primarily function in plasmid and chromosome partitioning, which is exemplified by ParB.

2023年11月25日 · VirB is a transcriptional activator of virulence in the gram-negative bacterium Shigella flexneri encoded by the large invasion plasmid, pINV. It counteracts the transcriptional silencing by the...

VirB is a key transcriptional regulator of genes found on the large virulence plasmid (pINV) (6, 7) which directly or indirectly leads to the upregulation of about 50 genes (7 – 9), including those encoding the type III secretion system, other crucial virulence-associated factors (OspZ, OspD1, and IcsP (10 – 12), and the transcriptional activato...

2024年1月5日 · Thus, VirB represents a CTP-dependent molecular switch that uses a loading-and-sliding mechanism to control transcription during bacterial pathogenesis. Shigella species are the causative agents...

2012年6月11日 · VirF promotes the transcription of virB, a gene encoding the transcriptional activator of several virulence-associated genes. This study reveals that transcription of virB is also regulated by the small RNA RyhB, and importantly, that this regulation is not achieved indirectly via modulation of VirF activity.

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2021年6月1日 · Our findings: 1) provide novel insight into VirB:pINV interactions, 2) suggest that VirB may have utility as a DNA marker, and 3) raise questions about how and why this anti-silencing protein that controls virulence gene expression on pINV of Shigella spp. forms discrete foci/hubs within the bacterial cytoplasm.

1997年2月1日 · During genetic transformation of plant cells by Agrobacterium tumefaciens, 11 VirB proteins and VirD4 are proposed to form a transmembrane bridge to transfer a DNA-protein complex (T-complex) into the plant cytoplasm. In this study, the localization of the first product of the virB operon, VirB1, was studied in detail.

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VirB is a transcriptional activator of virulence in the gram-negative bacterium Shigella flexneri encoded by the large invasion plasmid, pINV. It counteracts the transcriptional silencing by