A very-long-chain fatty acid (VLCFA) is a fatty acid with 22 or more carbons. Their biosynthesis occurs in the endoplasmic reticulum. [1] VLCFA's can represent up to a few percent of the total fatty acid content of a cell. [2]

Fatty acids (FAs) are highly diverse in terms of carbon (C) chain-length and number of double bonds. FAs with C>20 are called very long-chain fatty acids (VLCFAs). VLCFAs are found not only as constituents of cellular lipids such as sphingolipids and glycerophospholipids but also as precursors of lipid mediators.

Very long-chain fatty acids (VLCFAs) are fatty acids (FAs) with a chain-length of ≥22 carbons. Mammals have a variety of VLCFAs differing in chain-length and the number of double bonds. Each VLCFA exhibits certain functions, for example in skin barrier formation, liver homeostasis, myelin maintenanc …

Very long chain fatty acids (VLCFA) are monocarboxylic acids with a carbon chain length greater than 22. Small amounts are obtained from the diet but in humans the majority is biosynthesized from shorter chain fatty acids.

如果超长链脂肪酸（vlcfa）尤其是饱和脂肪酸在线粒体中代谢，ret会更频繁地发生，复合物i形成的ros会导致线粒体出现严重的氧化应激。 过氧化物酶体的β氧化

2020年3月5日 · ALD是一种遗传代谢病，因为ABCD1基因的突变，使得患者身体无法正常代谢极长链脂肪酸（VLCFA）。 Refsum综合症和Zellweger综合症等也会引起极长链脂肪酸水平异常。 VLCFA沉积在中枢……

VLCFA was the first biochemical marker identified for peroxisomal diseases. VLCFA (> C22) are exclusively degraded in the peroxisomal β-oxidation process. A defect in the process at one of the stages leads to the accumulation of this biochemical marker in body fluids and tissues [14].

2021年3月17日 · In a series of metabolome analyses, the levels of very long chain fatty acids (VLCFA) were shown to be elevated in CRC tissues, although the endogenous form of VLCFA has not been fully...

2022年2月1日 · Very long-chain fatty acids (VLCFAs) are hardly dissolved in aqueous medium. We report solubilization technique of VLCFAs in aqueous medium using isopropanol. Substantial amount of VLCFAs were found to be taken up in cultured animal cells. They were oxidatively degraded in peroxisomes without acylation to cellular lipids.

2007年8月24日 · Our results uncover a mutationally adjustable, caliper-like mechanism that generates the repertoire of cellular VLCFAs. Very long-chain fatty acids (VLCFAs) are structurally diverse biological molecules with unusually long hydrocarbon chains, ranging from 20 to 36 carbons (C20–36) or more (Leonard et al., 2004).