2018年6月5日 · In 293T cells transfected with Akt, VRK2, and Phafin2, we observed Akt interaction with Phafin2 and VRK2, but no interaction between Phafin2 and VRK2 was detected (Fig. 2e). This...

Human VRK2 (vaccinia-related kinase 2), a kinase that emerged late in evolution, affects different signaling pathways, and some carcinomas express high levels of VRK2. Invasion by cancer cells has been associated with NFAT1 (nuclear factor of activated T cells) activation and expression of the COX-2 (cyclooxygenase 2) gene.

VRK2 upregulation predicts poor prognosis in colorectal and 33 other cancers (TCGA/GTEx data). VRK2 deletion suppresses CRC proliferation/migration; overexpression enhances oncogenicity. VRK2 modulates E2F signaling via transcriptomics and luciferase assays. VRK2 links genomic instability to immunosuppressive tumor microenvironment.

2010年8月2日 · Vaccinia-related kinase (VRK) proteins are Ser-Thr kinases that regulate several signal transduction pathways. In this work, we study the effect of VRK2 on MAPK signaling using breast cancer as a model. High levels of VRK2 inhibit EGF and ErbB2 activation of transcription by the serum response element (SRE).

VRK2 (vaccinia-related kinase 2) is a novel Ser-Thr kinase 23 . VRK2 can interact with phosphorylated AKT after autophagy induction, controlling cellular proliferation and mitochondrial outer...

In the primary publication, we proposed that VRK2 is a unique therapeutic target and that combination of VRK2 inhibitors with PD-1 blockade may improve cancer immunotherapy. Here, we provide data on the effect of other kinases on PD-1 signaling utilizing shRNA knockdown of the different kinases in Jurkat T cells.

2012年12月12日 · Human VRK2 (vaccinia-related kinase 2), a kinase that emerged late in evolution, affects different signaling pathways, and some carcinomas express high levels of VRK2. Invasion by cancer cells has been associated with NFAT1 (nuclear factor of activated T cells) activation and expression of the COX-2 (cyclooxygenase 2) gene.

2018年6月5日 · In 293T cells transfected with Akt, VRK2, and Phafin2, we observed Akt interaction with Phafin2 and VRK2, but no interaction between Phafin2 and VRK2 was detected (Fig. (Fig.2e). 2e). This observation suggested that VRK2 directly interacted with Akt, but not through Phafin2.

2011年12月21日 · In this report the substrate specificity of atypical human vaccinia-related kinases (VRK1 and VRK2) using a human peptide-array containing 1080 sequences phosphorylated in known signaling pathways has been studied.

2011年8月4日 · VRK2 is more sensitive to roscovitine, RO 31–8220, Cdk1 inhibitor, AZD7762, and IC261. Vaccinia virus B1R is more sensitive to staurosporine, KU55933, and RO 31–8220, but not to IC261. Thus, the three kinases present a …