2024年12月22日 · Objectives: To describe the epidemiology, patient characteristics and comorbidities in patients with Wilson disease (WD) in the USA. Design: Retrospective, population-based study. Setting: The study used the US Komodo claims database containing records regarding medical claims for over 120 million individuals.

2019年9月11日 · Conclusions: H pylori treatment for two weeks and vitamin or garlic supplementation for seven years were associated with a statistically significant reduced risk of death due to gastric cancer for more than 22 years.

2020年11月4日 · Objective: To quantify the association of cancer treatment delay and mortality for each four week increase in delay to inform cancer treatment pathways. Design: Systematic review and meta-analysis. Data sources: Published studies in Medline from 1 …

We read with interest the recent article by Cai et al 1 describing the development of 5-hydroxymethylcytosine (5hmC)-based wd-scores that have better accuracy in diagnosing early hepatocellular carcinoma (HCC) than does α-fetoprotein (AFP).

Wilson disease (WD) is an autosomal recessive condition which leads to an excessive copper deposition in body organs, particularly in the liver and the central nervous system. 1 This genetic disorder is caused by mutations of the P-type ATPase copper transporter ATP7B gene located in the human chromosome 13. 2 To date, more than 600 variants in ...

⇒ This study estimated the diagnosed prevalence of Wilson disease (WD) for the first time in the USA, by using a large, nationally representative claims database. The real- world nature of the data helps estimate the observed frequency of WD in the USA using ICD- 10 (10th revision of the International Classification of Diseases) codes ...

2011年2月3日 · Objective: To review the association between current enterovirus infection diagnosed with molecular testing and development of autoimmunity or type 1 diabetes. Design: Systematic review and meta-analysis of observational …

D-penicillamine (DPA) is first line therapy for WD. Monitoring is conducted by performing 24-hour urinary copper excretions (UCE) and titrating the dose depending on the amount of copper excreted.

Notably, the 5hmC-based wd-scores consistently outperformed AFP in both training and validation sets for HCC versus non-HCC, early HCC versus CHB/LC, and early HCC versus controls (healthy individuals, benign liver lesions).

2020年11月4日 · Our analysis aims to provide robust evidence to guide national policy making, specifically the prioritisation and organisation of cancer services, by investigating the association between delays in receipt of cancer treatment and mortality.