2022年9月7日 · Esophageal squamous cell cancer (ESCC) is the major pathologic type of esophageal cancer in Asian population. To systematically evaluate the mutational features...

2024年5月2日 · Detecting early-stage esophageal squamous cell carcinoma (ESCC) and precancerous lesions is critical for improving survival. Here, we conduct whole-genome bisulfite...

Chinese Cancer Genomic Database-Esophageal Squamous Cell Carcinoma (CCGD-ESCC) is a comprehensive database for searching the associations of single nucleotide polymorphisms (SNPs) with the risk of ESCC (genome-wide association studies, GWASs), patients’ survival (Survival GWAS) or gene expression (expression quantitative trait loci, eQTLs).

2020年5月12日 · This study provides the most comprehensive characterization of ESCC genomes, to date, using deep WGS in a large Chinese patient cohort with clinical follow-up data.

2024年5月27日 · 为了提高ESCC的早期检测，作者开发了基于“组织- cfDNA-组织”策略的EMMA框架 (下图a)，全面分析cfDNA WGBS数据中的癌症衍生的差异甲基化区域（DMRs）、拷贝数变异（CNVs）和片段特征。 肿瘤来源的DMRs和CNVs是从155例ESCC患者的原发肿瘤和配对组织中的WGBS和WGS数据确定的。 随后，在cfWGBS数据中检测了ESCC衍生的DMRs和CNVs，以及短cfDNA片段大小的比例（FSRs）来训练诊断模型。 在外部ESCC队列和癌前病变队列中独 …

2022年1月21日 · To explore the potential therapeutic targets of ESCC, we integrated and reanalyzed the mutation data of WGS (whole genome sequencing) or WES (whole exome sequencing) from a total of 1,145 samples in 7 large ESCC cohorts, including 270 ESCC gene expression data.

2024年3月11日 · 食管癌是一种常见的恶性肿瘤，有两种亚型：鳞状细胞癌（squamous cell carcinoma，ESCC）和腺癌（adenocarcinoma，EAC）。 区分细胞类型特异性分子特征和癌症特异性特征具有挑战性。 表观遗传学上，多项研究报告了食管癌中的分子变化，特别是在DNA甲基化水平上，食管癌的DNA甲基化组需要通过全基因组单碱基分辨率方法（如全基因组重亚硫酸盐测序，WGBS）进行全面表征。

In this study, we performed WGS, WGBS, RNA sequencing, and small RNA sequencing on tumor tissues as well as matched adjacent non-neoplastic tissues from ESCC patients to discover potential molecular subgroups.

2024年4月2日 · Coupled with the RNA-seq and whole-genome bisulfite sequencing (WGBS) of the 155 ESCC pairs therein, we present the most comprehensive multi-omics features of mtDNA in ESCC, extending the current understanding of ESCC etiology.

2016年4月4日 · In this study, 67 somatic genomes of ESCC were comprehensively characterized via WGS and WES. We described a landscape of genetic lesions, including somatic SNVs, small indels, and SVs and/or SCNAs.