2020年12月29日 · Worst pattern of invasion (WPOI) (AJCC: Cancer Staging [Accessed 21 September 2018], CAP: Protocol for the Examination of Specimens from Patients with Cancers of the Lip and Oral Cavity [Accessed 29 December 2020]): Validated outcome predictor for oral cavity squamous carcinoma patients in multivariate analysis

We analyzed the results comparing, early and advanced T (Tumor) stages, cohesive WPOI I-III, non-cohesive WPOI IV-V. Univariate analysis showed a significant association of T-stage (p = 0.001), N (Nodal) -stage (p = 0.002), DOI (p = 0.008), PNI (Peri-neural invasion) (0.001) and Tumor differentiation Grade (p = 0.001).

2023年10月18日 · WPOI is predictive of disease free survival in oral cancer. WPOI is described as five patterns - but generally divided into two (prognostic) groups: WPOI 1-4: better prognosis. WPOI 5: poor prognosis. Definition of WPOI 5. WPOI 5 is defined as >=1 mm normal tissue between two tumour masses. See also. Tumour budding. Spread through air spaces.

2024年3月1日 · This study analyses the prognostic significance of worst pattern of invasion (WPOI) in a unique population of pathologically proven node-negative early-stage oral tongue cancer patients to see if the WPOI is a prognostic marker …

The current study is the first demonstration that WPOI-5 significantly predicts OCM for pT1 OSC. Thirteen pT1 patients had occult cervical metastases; 10 with WPOI-5, 2 with WPOI-4, and 1 with WPOI-3 (Table 1). Most pT1 WPOI-5 carcinomas are clustered at a DOI between 4 and 5 mm, thus these patients would have received END based on DOI.

Regional lymph node recurrence rates were significantly higher for WPOI-4/5 than for WPOI-1 to -3 (p=0.0065), and correlated more strongly with WPOI than with pT staging. Table II. Five-year regional lymph node recurrence and disease-specific survival.

结果 涉及 3954 名患者的 18 项研究表明，与 WPOI 为 1 至 3 的患者相比，WPOI 为 4 至 5 的患者的总生存期、疾病特异性生存期和无病生存期显着较差。 WPOI 与局部区域复发显着相关并发现死亡率。 结论 在各种结局中，较高的 WPOI 与 OSCC 的较差预后显着相关。 将 WPOI 纳入标准组织病理学评估可以指导个性化治疗并改善结果。 Impact of worst pattern of invasion on prognosis of oral squamous cell carcinoma: a systematic review and meta-analysis.

2018年4月19日 · WPOI-4 tumors are defined as having small tumor islands (≤15 cells per island) that are discontinuous, or convincingly separated from the main tumor mass. WPOI-5 tumors are recognized by a dispersed, discontinuous growth pattern, and the degree of tumor dispersion exceeds that seen for WPOI-4 tumors with a defined cutoff of 1 mm.

2024年11月29日 · To examine the impact of the worst patterns of invasion (WPOI) on survival outcomes and possible implications for adjuvant treatment decisions in squamous cell oral cavity cancer patients. The loco-regional progression-free survival (LRPFS) and the distant metastasis-free survival (DMFS) were calculated for 162 patients.

2023年2月28日 · Frozen section analysis of oral cancer specimens is ideal for assessing margin distances and depth of invasion (DOI); the latter impacts intraoperative decisions regarding elective neck dissection (END). Here, we show that intraoperative determination of worst pattern of invasion (WPOI), specifically WPOI-5, has a high level of accuracy.