2019年5月17日 · Polyubiquitination by the ubiquitin E3 ligase WWP1 (WW domain-containing ubiquitin E3 ligase 1) suppressed the dimerization, membrane recruitment, and function of PTEN. Either genetic ablation or pharmacological inhibition of WWP1 triggered PTEN reactivation and unleashed tumor suppressive activity.

2019年5月17日 · We found that WWP1 specifically triggers nondegradative K27-linked polyubiquitination of PTEN to suppress its dimerization, membrane recruitment, and tumor-suppressive functions both in vitro and in vivo.

2020年5月28日 · The prioritized WWP1 variants resulted in gain-of-function effects, which led to aberrant enzymatic activation with consequent PTEN inactivation, thereby triggering hyperactive growth-promoting PI3K signaling in cellular and murine models.

2020年5月27日 · In this study involving patients with disorders resulting in a predisposition to the development of multiple malignant neoplasms without PTEN germline mutations, we confirmed the function of...

2024年12月2日 · In luminal breast cancer cells, WWP1 was found to mediate PTEN ubiquitination, resulting in the functional loss of PTEN. As a result, we demonstrate that WWP1 contributes to bone tropism in...

2019年6月10日 · 证明wwp1引起pten聚泛素化，从而抑制pten的二聚化和膜定位，使其不能发挥抑癌作用; 发现并验证myc-wwp1-pten调控信号链; 通过结构模拟和生化分析得到一个wwp1的潜在抑制剂ic3（来源于十字花科蔬菜）

2024年12月2日 · In luminal breast cancer cells, WWP1 was found to mediate PTEN ubiquitination, resulting in the functional loss of PTEN. As a result, we demonstrate that WWP1 contributes to bone tropism in luminal breast cancer cells via the polyubiquitination of PTEN.

wwp1优先变异造成功能获得效应，导致异常的酶促激活和pten失活，从而在细胞和小鼠模型中触发高活性促生长pi3k信号。 总之，研究组通过PTEN-PI3K信号轴的直接异常调节，证实了WWP1作为一种癌症易感基因的功能，该基因涉及那些易患多发性恶性肿瘤且无PTEN种系 ...

2021年6月21日 · Emerging evidence demonstrates that WW domain-containing E3 ubiquitin protein ligase 1 (WWP1) participates into carcinogenesis and tumor progression. In this review article, we will describe the...

2019年6月7日 · wwp1常在多种癌症中过度表达，包括前列腺癌，乳腺癌和肝癌，这可能导致pten的多效性失活。研究人员发现，wwp1可以通过原癌基因myc表达产物进行 ...