2018年11月8日 · 人类白细胞抗原 ( HLA )分子由基因组的主要组织相容性复合体 ( MHC )区域编码，是细胞表面糖蛋白，负责呈现内源性和外源性衍生的肽抗原，用于免疫监测。 将新的复合物引入该阵列，例如含有来自入侵病原体的肽的复合物，刺激对感染细胞的免疫反应。 编码HLA分子的基因 (经典HLA I类分子为HLA - 我在真理教的日子2、- B和- C，HLA II类分子为HLA - DP、- DQ和- DR )是人类基因组多态性最强的基因，仅HLA - B就拥有3000多种功能变体1。 HLA I类分子的 …

人類白細胞抗原（英語： Human leukocyte antigen ，缩写： HLA ），是編碼人类的主要组织相容性复合体（MHC）的基因。 其位于 6号染色体 的短臂上（6p21.31），包括一系列紧密连锁的 基因座 ，与人类的 免疫系统 功能密切相关。

2018年11月8日 · Here we explore the impact of micropolymorphism on peptide antigen presentation by three closely related HLA molecules, HLA-B*57:01, HLA-B*57:03 and HLA-B*58:01, that are differentially...

2018年1月2日 · Here, we review our current understanding of HLA molecules as the fundamental platform for immune surveillance and responsiveness in health and disease. We evaluate the scope for personalized...

HLA-B*57 is the HLA allele that has the greatest impact on the viral-load set point and the rate of disease progression in HIV infection (10, 17, 18, 23, 28, 29, 34, 42, 46, 55). However, critically for the development of a vaccine designed to optimize immune control of HIV infection, the mechanism by which HLA-B*57 is linked to relatively ...

2017年9月1日 · We developed a novel hydrolysis probe–based real-time PCR method of HLA-B*57:01 genotyping. Primer and probes were designed based on published sequence variations in exon 3 of HLA-B that distinguish HLA-B*57:01 from ABC-insensitive alleles such as HLA-B*57:03 and HLA-B*58:01.

Different genetic assays have been developed for HLA-B*57: 01 screening, each with specific sensitivity, turnaround time and assay costs.

HLA-B57 is a host genetic determinant associated with better virus control and slower disease progression in HIV-infected individuals. You might find these chapters and articles relevant to this topic. There are a number of host genetic determinants that influence susceptibility to infection or the rate of progression to AIDS (Table 3).

2018年11月8日 · Immunophenotypic differences between closely related human leukocyte antigen (HLA) alleles have been associated with divergent clinical outcomes in infection, autoimmunity, transplantation and drug hypersensitivity. Here we explore the impact of micropolymorphism on peptide antigen presentation by t …

HIV control is strongly associated with the expression of human leukocyte antigen (HLA) alleles in HICs. From the HIV protective HLAs described, HLA-B57 is the most frequent in HIC patients. HLA-B57 can present a large range of highly conserved Gag-derived HIV peptides to CD8 + T cells and natural killer (NK) cells, both the focus of this review.