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WDHA (watery diarrhea, hypokalemia, and achlorhydria) syndrome is an unusual paraneoplastic condition caused by excess vasoactive intestinal polypeptide (VIP) secreted by certain tumors. The onset of the syndrome is insidious, and diagnosis is usually delayed by months to years.

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2020年7月16日 · 为了探索circRNA表达随年龄的动态变化，作者对野生型(WDah)果蝇和长寿的三个胰岛素样多肽（dilp 2-3，5）突变果蝇进行全转录水平的深度测序。 作者解剖了幼龄(出生后第10天)、中年(出生后第30天)和老年(出生后第50天)果蝇的四个主要成虫组织(脑、有马氏管的肠管 ...

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Circular RNAs are a poorly characterized class of non-coding RNAs that accumulate with age in diverse species. In this study, Weigelt et al. identify a circular RNA that is specifically regulated in long-lived insulin mutant flies and extends the lifespan of fruit flies.

white Dahomey (wDah) is a strain created in the Partridge Lab and was derived by repeated backcrossing of the mutated w gene from w1118 into the outbred wild-type Dahomey strain.

white Dahomey (wDah) is a strain created in the Partridge Lab and was derived by repeated backcrossing of the mutated w gene from w1118 into the outbred wild-type Dahomey strain. The Dahomey strain was originally collected in Dahomey, now Benin (Puijk & de Jong, 1972 ), and has been maintained since then in large population cages with ...

2022年8月1日 · Age dependent gene and transposon expression in male wildtype (wDAH) and FOXO deletion (wDAH ∆94) fly strains. Transposable elements (TE) are mobile sequences of DNA that can become transcriptionally active as an animal ages. Activation of the stress response transcription factor FOXO can increase longevity in flies and worms.

2020年7月16日 · The outbred wild-type strain white Dahomey (wDah) (Grönke et al., 2010) that naturally carries the endosymbiontic bacterium Wolbachia was used for all experiments and maintained in large population cages with overlapping generations. All mutations and transgenic constructs were backcrossed into the white Dahomey (wDah) wild-type background for ...