2016年2月8日 · We observed that stiff ECM significantly enhanced the expression level of several members of the Wnt/β-catenin pathway in both bone marrow mesenchymal stem cells and primary chondrocytes. The...

2023年4月21日 · Here, we report that Wnt/β-catenin signaling induces the ECM remodeling during Hydra axis formation. We determined the micro- and nanoscopic arrangement of fibrillar type I collagen along Hydra’s body axis using high-resolution microscopy and X-ray scattering.

2022年1月3日 · sFRPs, WIF, glypicans, Tiki, and Notum are well-known regulators of Wnt/β-catenin signalling that target Wnt proteins to affect signal transduction. sFRPs have a Netrin-related motif in the C...

2023年6月4日 · Wnt信号通路 是胚胎及器官发育的重要信号通路之一，参与调控机体内多种细胞的增殖、分化、极化、迁移及凋亡等过程。 Wnt信号通路根据是否依赖于 β-catenin 的转录活化，可分为经典通路（即 Wnt／β-catenin信号通路）和非经典通路（包括Wnt／PCP通路和 Wnt-Ca2+通路）。 2017年5月，美国斯坦福大学医学院的 Roel Nusse 教授和荷兰乌得勒支大学医学中心 Hans Clevers 教授在《Cell》期刊（IF=66.89）上发表题为“ Wnt/b-Catenin Signaling, Disease, and …

2025年2月19日 · The Wnt-driven increase in cell-cell adhesion is counterbalanced by higher cell-ECM forces, which becomes concentrated around the rim of multicellular colonies. Increased cadherin-based adhesions, supported by organized junctional actin filaments, enhance collective durotaxis by promoting synchrony between cells over speed.

2017年7月25日 · Here, we demonstrate an important role for Wnt/β-catenin signaling in controlling the composition of the spinal lesion ECM, which is essential for functional axon regeneration in zebrafish.

2022年2月28日 · Here, we report that Mmp14-dependent ECM remodeling coordinates canonical Wnt signaling and guides stem cell fate by triggering an integrin-activated reorganization of the SCC cytoskeleton that controls nuclear lamin A/C levels via the linker of nucleoskeleton and cytoskeleton (LINC) complexes.

2014年10月28日 · In this study, we examine the role of canonical Wnt signaling on extracellular matrix (ECM) expression in the trabecular meshwork (TM) and explore the molecular mechanisms involved. Methods: β-catenin localization in human TM tissue was examined using immunofluorescent staining.

ECM elasticity patterns. This suggests a mechanism whereby high protease activity under control of Wnt/b-catenin signaling causes remodeling and soft-ening of the ECM. This Wnt-dependent spatiotemporal coordination of biochem-ical and biomechanical cues in ECM formation was likely a central evolutionary innovation for animal tissue morphogenesis.

微载体刚度的增加抑制了 hAEC 的增殖和上皮表型维持，除了激活 Wnt/β-catenin 信号通路外，这与细胞外基质 （ECM） 和 ECM-整合素相互作用的重塑有关。 这些发现为 hAECs 增殖的机械调节和 hAECs 表型提供了新的见解，为它们的放大铺平了道路。