Wnt signaling and stem cell control | Cell Research - Nature
2008年4月8日 · Wnt signaling has been implicated in the control over various types of stem cells and may act as a niche factor to maintain stem cells in a self-renewing state. As currently understood, Wnt...
Melanoma-intrinsic β-catenin signalling prevents anti-tumour
2015年5月11日 · Here we identify a melanoma-cell-intrinsic oncogenic pathway that contributes to a lack of T-cell infiltration in melanoma. Molecular analysis of human metastatic melanoma samples revealed a...
Melanoma-intrinsic β-catenin signalling prevents anti-tumour immunity
2015年7月9日 · Molecular analysis of human metastatic melanoma samples revealed a correlation between activation of the WNT/β-catenin signalling pathway and absence of a T-cell gene expression signature. Using autochthonous mouse melanoma models we identified the mechanism by which tumour-intrinsic active β-catenin signalling results in T-cell exclusion and ...
来看！为你翻译了这篇Cell综述，不再遗憾错过Wnt信号通路 - 知乎
2023年6月4日 · Wnt信号通路 是胚胎及器官发育的重要信号通路之一，参与调控机体内多种细胞的增殖、分化、极化、迁移及凋亡等过程。 Wnt信号通路根据是否依赖于 β-catenin 的转录活化，可分为经典通路（即 Wnt／β-catenin信号通路）和非经典通路（包括Wnt／PCP通路和 Wnt-Ca2+通路）。 2017年5月，美国斯坦福大学医学院的 Roel Nusse 教授和荷兰乌得勒支大学医学中心 Hans Clevers 教授在《Cell》期刊（IF=66.89）上发表题为“ Wnt/b-Catenin Signaling, Disease, and …
Wnt/β-catenin 信号通路 - CSDN博客
2024年11月28日 · 经典 Wnt 通路，也称为 Wnt/β-catenin 通路，涉及 β-catenin 的核转位和通过 TCF/LEF 转录因子激活靶基因。 核段主要包括 β-catenin，它易位到细胞核、TCF/LEF 家族成员和 β-catenin 下游靶基因，如 MMPs 和 c-Myc。
Pharmacologically Targeting the WNT/β-Catenin Signaling …
WNT/β-catenin signaling plays fundamental roles in numerous developmental processes and in adult tissue homeostasis and repair after injury, by controlling cellular self-renewal, activation, division, differentiation, movement, genetic stability, and apoptosis.
Chondrocytes-derived exosomal miR-8485 regulated the Wnt/β ... - PubMed
2020年3月5日 · Mechanistically, exosomal miR-8485 targeted GSK3B to repress GSK-3β expression and targeted DACT1 to induce p-GSK-3β (Ser9), activating Wnt/β-catenin pathways. Our study firstly showed that chondrocytes-derived exosomal miR-8485 regulated the Wnt/β-catenin pathways to promote chondrogenic differentiation of BMSCs, providing innovative ...
Human WNT-3a Matched Antibody Pair Set [ABP-P-523]
The antibody pair set can be used to detect Human WNT-3a by sandwich ELISA. This antigen affinity purified capture antibody, combined with biotinylated detection antibody, allows for the detection of recombinant WNT-3a.
- 评论数: 1
Sci-Hub | Inhibiting Wnt/beta‐catenin in CTNNB1 ‐mutated …
Inhibiting Wnt/beta‐catenin in CTNNB1 ‐mutated endometrial cancer. Molecular Carcinogenesis, 60(8), 511–523. doi:10.1002/mc.23308 10.1002/mc.23308
Wnt-β-catenin（β-联蛋白）信号通路 - 知乎 - 知乎专栏
Wnt-β-catenin信号通路是胚胎发育中最重要的调控途径之一，对多细胞生物体轴的形成和分化、组织器官建成、组织干细胞的更新与分化等至关重要。 Wnt信号通路的异常活化导致或参与多种人类疾病的发生发展，如 肿瘤的发生 、神经系统退行性疾病（如阿尔兹海默病）等。 Wnt是一组富含半胱氨酸的分泌性糖蛋白，作为局域性信号分子，广泛存在于各种动物多种组织中。 由于某些乳腺癌的发生与它的过度表达有关，所以Wnt基因倍受关注。 β-catenin是哺乳类中与果蝇Arm蛋白 …