2011年6月6日 · We found that AMPK activation suppressed Wnt/β-catenin signals via diminished β-catenin levels. This crosstalk between AMPK and the Wnt/β-catenin signaling pathway may …

Biochemical, metabolomic, confocal microscopy and mouse genetics experiments all demonstrate coordinated activation of Wnt signaling, predominantly in neurons, and the ensuing induction …

We now report that several “Wnt inhibitors” that allegedly target β-catenin actually function as mitochondrial proton uncouplers that independently activate AMPK and concomitantly inhibit …

2024年6月20日 · An AMPK inhibitor accelerates activation of dormant follicles in murine in vitro-cultured ovaries, accompanied with an upregulation of Wnt and FOXO genes, phosphorylation …

Our results indicate that HNF4α is a targetable oncoprotein in GC, is regulated by AMPK signalling through AMPKα and resides upstream of WNT signalling. HNF4α may regulate …

2023年10月24日 · In this work, we found that LKB1/AMPK axis activation leads to the inhibition of Wnt/β-catenin through phosphorylation of USP10. Mechanism-wise, AMPK-phosphorylated …

2021年8月6日 · This split Warburg metabolic reprogramming triggers an inhibition of AMPK and subsequent activation of mTOR, which is a signature event of epileptogenesis. Interrogation of …

WIF1 增加线粒体中的 ΔΨm 并下调线粒体自噬相关蛋白的表达，包括 Parkin、Pink1、LC3-II/LC3-I 比率、切割的半胱天冬酶 3 和 cyt-c，从而改善线粒体功能障碍。体内研究进一步证明了 WIF1 …

AMPK 是重要的调节寿命通路，可有效调控细胞自噬和抑制mTor，其更类似于在恶劣情况下的适应性机制。 这篇Review详细介绍了如何AMPK信号通路，由复旦药学院Doctor candidate Freda …

2011年6月6日 · AMP-activated protein kinase (AMPK) is a key sensor of cellular energetic conditions. Recent studies suggest that AMPK affects osteoblast differentiation, although its …