Extracellular matrix stiffness dictates Wnt expression through integrin ...
2016年2月8日 · We observed that stiff ECM significantly enhanced the expression level of several members of the Wnt/β-catenin pathway in both bone marrow mesenchymal stem cells and …
Wnt/β-catenin signaling induces axial elasticity patterns of
2023年4月21日 · Here, we report that Wnt/β-catenin signaling induces the ECM remodeling during Hydra axis formation. We determined the micro- and nanoscopic arrangement of fibrillar …
Wnt/β-catenin signalling: function, biological mechanisms, …
2022年1月3日 · sFRPs, WIF, glypicans, Tiki, and Notum are well-known regulators of Wnt/β-catenin signalling that target Wnt proteins to affect signal transduction. sFRPs have a Netrin …
来看！为你翻译了这篇Cell综述，不再遗憾错过Wnt信号通路 - 知乎
2023年6月4日 · Wnt信号通路 是胚胎及器官发育的重要信号通路之一，参与调控机体内多种细胞的增殖、分化、极化、迁移及凋亡等过程。 Wnt信号通路根据是否依赖于 β-catenin 的转录活 …
Wnt signaling modulates mechanotransduction in the epidermis …
2025年2月19日 · The Wnt-driven increase in cell-cell adhesion is counterbalanced by higher cell-ECM forces, which becomes concentrated around the rim of multicellular colonies. Increased …
Wnt signaling controls pro-regenerative Collagen XII in functional ...
2017年7月25日 · Here, we demonstrate an important role for Wnt/β-catenin signaling in controlling the composition of the spinal lesion ECM, which is essential for functional axon …
Matrix remodeling controls a nuclear lamin A/C-emerin network …
2022年2月28日 · Here, we report that Mmp14-dependent ECM remodeling coordinates canonical Wnt signaling and guides stem cell fate by triggering an integrin-activated reorganization of the …
Canonical wnt signaling regulates extracellular matrix expression …
2014年10月28日 · In this study, we examine the role of canonical Wnt signaling on extracellular matrix (ECM) expression in the trabecular meshwork (TM) and explore the molecular …
ECM elasticity patterns. This suggests a mechanism whereby high protease activity under control of Wnt/b-catenin signaling causes remodeling and soft-ening of the ECM. This Wnt-dependent …
微载体刚度通过重塑 ECM 和 Wnt/β-catenin 通路控制人羊膜上皮 …
微载体刚度的增加抑制了 hAEC 的增殖和上皮表型维持，除了激活 Wnt/β-catenin 信号通路外，这与细胞外基质 （ECM） 和 ECM-整合素相互作用的重塑有关。 这些发现为 hAECs 增殖的机 …