2020年9月15日 · RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by inducing degradation of the Wnt receptor Frizzled. In this study, we discover that RNF43 activity requires phosphorylation at a triplet of conserved serines.

2025年1月3日 · Our findings unveil how LGR4 content mediates diverse assemblies, leading to conformational rearrangements in ZNRF3 to regulate WNT/β-catenin signaling, and provide a structural foundation for...

2020年9月15日 · RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by inducing degradation of the Wnt receptor Frizzled. In this study, we discover that RNF43 activity requires phosphorylation at...

2023年11月13日 · Loss-of-function studies have shown that RNF2 consistently destabilizes nuclear TCF7L1 and is required for proper Wnt target gene transcription in response to Wnt activation. Furthermore, our...

2020年9月17日 · RNF43是一种E3泛素连接酶，可以通过诱导Frizzled（卷曲蛋白，Wnt信号通路受体蛋白）的降解来负调控Wnt信号转导通路。 该研究发现RNF43保守性丝氨酸三联体的磷酸化是该蛋白活性状态所必需的。

2021年6月14日，瑞士诺华生物医药研究院Jan Tchorz团队在 Cell Stem Cell 发表题为“ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation” 的论文。 该研究探索了肝脏与小肠区别利用WNT/β-Catenin信号通路调节自身代谢与增殖的机理，并且解析了ZNRF3和RNF43协同调控肝细胞增值和肝脏代谢分区 (metabolic liver zonation)的机制。 瑞士诺华生物医药研究院 孙天亮 博士和 Jan Tchorz 博士为该论文的共同通讯作者， 孙天亮 博士为第 …

2023年11月30日 · These E3 ubiquitin ligases control Wnt signaling by targeting the Wnt receptor Frizzled to induce ubiquitination-mediated endo-lysosomal degradation, thus controlling the activation of the Wnt signaling pathway. We also discuss the regulatory mechanisms, interactors, and evolution of RNF43 and ZNRF3.

RNF43 是一种 E3 泛素连接酶，通过诱导 Wnt 受体 Frizzled 降解来负调节 Wnt 信号传导。 在这项研究中，我们发现 RNF43 活性需要在保守的丝氨酸三联体上进行磷酸化。

These E3 ubiquitin ligases control Wnt signaling by targeting the Wnt receptor Frizzled to induce ubiquitination-mediated endo-lysosomal degradation, thus controlling the activation of the Wnt signaling pathway. We also discuss the regulatory mechanisms, interactors, and evolution of RNF43 and ZNRF3.

The canonical Wnt (Wnt/β-catenin) signalling pathway is highly conserved and plays a critical role in regulating cellular processes both during development and in adult tissue homeostasis. The Wnt/β-catenin signalling pathway is vital for correct body patterning and is involved in fate specification of the gut tube, the primitive precursor of ...