
A phospho-switch controls RNF43-mediated degradation of Wnt …
2020年9月15日 · RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by inducing degradation of the Wnt receptor Frizzled. In this study, we discover that RNF43 activity requires phosphorylation at a triplet of conserved serines.
Structural insights into the LGR4-RSPO2-ZNRF3 complexes regulating WNT ...
2025年1月3日 · Our findings unveil how LGR4 content mediates diverse assemblies, leading to conformational rearrangements in ZNRF3 to regulate WNT/β-catenin signaling, and provide a structural foundation for...
A phospho-switch controls RNF43-mediated degradation of Wnt ... - Nature
2020年9月15日 · RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by inducing degradation of the Wnt receptor Frizzled. In this study, we discover that RNF43 activity requires phosphorylation at...
RNF2 regulates Wnt/ß-catenin signaling via TCF7L1 destabilization …
2023年11月13日 · Loss-of-function studies have shown that RNF2 consistently destabilizes nuclear TCF7L1 and is required for proper Wnt target gene transcription in response to Wnt activation. Furthermore, our...
Nat Commun:磷酸化状态:RNF43的抑癌开关 - MedSci
2020年9月17日 · RNF43是一种E3泛素连接酶,可以通过诱导Frizzled(卷曲蛋白,Wnt信号通路受体蛋白)的降解来负调控Wnt信号转导通路。 该研究发现RNF43保守性丝氨酸三联体的磷酸化是该蛋白活性状态所必需的。
ZNRF3/RNF43通过协调WNT/β-Catenin信号通路来平衡肝细胞增 …
2021年6月14日,瑞士诺华生物医药研究院Jan Tchorz团队在 Cell Stem Cell 发表题为“ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation” 的论文。 该研究探索了肝脏与小肠区别利用WNT/β-Catenin信号通路调节自身代谢与增殖的机理,并且解析了ZNRF3和RNF43协同调控肝细胞增值和肝脏代谢分区 (metabolic liver zonation)的机制。 瑞士诺华生物医药研究院 孙天亮 博士和 Jan Tchorz 博士为该论文的共同通讯作者, 孙天亮 博士为第 …
RNF43 and ZNRF3 in Wnt Signaling - A Master Regulator at the
2023年11月30日 · These E3 ubiquitin ligases control Wnt signaling by targeting the Wnt receptor Frizzled to induce ubiquitination-mediated endo-lysosomal degradation, thus controlling the activation of the Wnt signaling pathway. We also discuss the regulatory mechanisms, interactors, and evolution of RNF43 and ZNRF3.
磷酸开关控制 RNF43 介导的 Wnt 受体降解以抑制肿瘤发生 …
RNF43 是一种 E3 泛素连接酶,通过诱导 Wnt 受体 Frizzled 降解来负调节 Wnt 信号传导。 在这项研究中,我们发现 RNF43 活性需要在保守的丝氨酸三联体上进行磷酸化。
RNF43 and ZNRF3 in Wnt Signaling - A Master Regulator at the …
These E3 ubiquitin ligases control Wnt signaling by targeting the Wnt receptor Frizzled to induce ubiquitination-mediated endo-lysosomal degradation, thus controlling the activation of the Wnt signaling pathway. We also discuss the regulatory mechanisms, interactors, and evolution of RNF43 and ZNRF3.
The Canonical Wnt Pathway as a Key Regulator in Liver …
The canonical Wnt (Wnt/β-catenin) signalling pathway is highly conserved and plays a critical role in regulating cellular processes both during development and in adult tissue homeostasis. The Wnt/β-catenin signalling pathway is vital for correct body patterning and is involved in fate specification of the gut tube, the primitive precursor of ...
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