A phospho-switch controls RNF43-mediated degradation of Wnt …
2020年9月15日 · RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by inducing degradation of the Wnt receptor Frizzled. In this study, we discover that RNF43 activity …
Structural insights into the LGR4-RSPO2-ZNRF3 complexes regulating WNT ...
2025年1月3日 · Our findings unveil how LGR4 content mediates diverse assemblies, leading to conformational rearrangements in ZNRF3 to regulate WNT/β-catenin signaling, and provide a …
A phospho-switch controls RNF43-mediated degradation of Wnt ... - Nature
2020年9月15日 · RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by inducing degradation of the Wnt receptor Frizzled. In this study, we discover that RNF43 activity …
RNF2 regulates Wnt/ß-catenin signaling via TCF7L1 destabilization …
2023年11月13日 · Loss-of-function studies have shown that RNF2 consistently destabilizes nuclear TCF7L1 and is required for proper Wnt target gene transcription in response to Wnt …
Nat Commun：磷酸化状态：RNF43的抑癌开关 - MedSci
2020年9月17日 · RNF43是一种E3泛素连接酶，可以通过诱导Frizzled（卷曲蛋白，Wnt信号通路受体蛋白）的降解来负调控Wnt信号转导通路。 该研究发现RNF43保守性丝氨酸三联体的磷酸 …
ZNRF3/RNF43通过协调WNT/β-Catenin信号通路来平衡肝细胞增 …
2021年6月14日，瑞士诺华生物医药研究院Jan Tchorz团队在 Cell Stem Cell 发表题为“ZNRF3 and RNF43 cooperate to safeguard metabolic liver zonation and hepatocyte proliferation” 的论文。 …
RNF43 and ZNRF3 in Wnt Signaling - A Master Regulator at the
2023年11月30日 · These E3 ubiquitin ligases control Wnt signaling by targeting the Wnt receptor Frizzled to induce ubiquitination-mediated endo-lysosomal degradation, thus controlling the …
磷酸开关控制 RNF43 介导的 Wnt 受体降解以抑制肿瘤发生 …
RNF43 是一种 E3 泛素连接酶，通过诱导 Wnt 受体 Frizzled 降解来负调节 Wnt 信号传导。 在这项研究中，我们发现 RNF43 活性需要在保守的丝氨酸三联体上进行磷酸化。
RNF43 and ZNRF3 in Wnt Signaling - A Master Regulator at the …
These E3 ubiquitin ligases control Wnt signaling by targeting the Wnt receptor Frizzled to induce ubiquitination-mediated endo-lysosomal degradation, thus controlling the activation of the Wnt …
The Canonical Wnt Pathway as a Key Regulator in Liver …
The canonical Wnt (Wnt/β-catenin) signalling pathway is highly conserved and plays a critical role in regulating cellular processes both during development and in adult tissue homeostasis. The …
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