2024年12月25日 · XBP1 (X-Box Binding Protein 1) is a Protein Coding gene. Diseases associated with XBP1 include Major Affective Disorder 7 and Hematologic Cancer. Among its related pathways are Unfolded Protein Response (UPR) and Cellular responses to stimuli.

The X-box binding protein 1 (XBP1) is a transcription factor containing a bZIP domain. It was first identified by its ability to bind to the Xbox, a conserved transcriptional element in the promoter of the human leukocyte antigen (HLA) DR alpha .

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter.

As the most conserved signaling branch of UPR, the IRE1-XBP1 pathway plays an important role in both physiological and pathological states, and its activity has a profound impact on disease progression and prognosis.

This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter.

X-盒结合蛋白1 (XBP-1)是未折叠蛋白反应的重要组分,有剪接型XBP-1 (XBP-1S)和非剪接型XBP-1 (XBP-1U)两种形式。 当细胞处于内质网应激状态时,XBP-1由活化转录因子6 (ATF6)诱导,经IRE1α非传统剪接,转录有功能的XBP-1S,活化未折叠蛋白反应。 XBP-1是一种重要的转录因子,对细胞生长和分化具有重要调控作用,并与人类多种疾病的发生和发展相关。 百度学术集成海量学术资源，融合人工智能、深度学习、大数据分析等技术，为科研工作者提供全面快捷的学术服务。 …

2025年2月8日 · This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter.

2016年10月18日 · This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter.

2014年1月23日 · xbp-1与活化的蛋白激酶d (pkd)结合可以介导eb病毒(ebv)再激活。 xbp-1表达和pkd活化可以充分诱导ebv阳性的鼻咽癌细胞和淋巴样干细胞内裂解期ebv基因表达。 研究发现人t细胞白血病病毒,htlv-1 ,感染的宿主细胞可能触发了未折叠蛋白反应(14) 。

X-盒结合蛋白1（X-box binding protein，XBP-1）是Liou等人于1990年克隆得到，因与靶基因启动子序列的X盒结合而得名。 它是一种碱性亮氨酸拉链（basic leucine zipper，bZIP）结构蛋白，属于CREB/ATF（cyclic AMP response element binding protein/activating transcription factor）蛋白 …