Oxford® Partial Knee Replacement (PKR) •ee the package insert for complete indications, contraindications and S patient selection criteria • Recommended X-rays: AP weight bearing, true lateral, valgus stress & skyline. (Varus stress or Rosenberg/standing PA 20° flexion if bone-on-bone not seen on AP X-ray)

(Right) An X-ray of a normal knee joint showing healthy space between the bones. Advanced osteoarthritis that is limited to a single compartment may be treated with a unicompartmental knee replacement. During this procedure, the damaged compartment is replaced with metal and plastic.

PKR provides better function than TKR, and patietns with PKR tend to be more active than those with TKR. The leg is more likely to have its normal alignment and contour restored and has a greater range of movement. The chance of a patient needing further surgery to the knee is lower after PKR than TKR.

2024年5月22日 · The Oxford PKR is indicated for individuals with osteoarthritis or avascular necrosis limited to the medial compartment of the knee. It is contraindicated for use in the lateral compartment, patients with ligament deficiency, and in cases with full thickness damage to the weight-bearing area of the lateral compartment.

2023年2月1日 · The crystals of the full-length PK2 and the N-terminal truncated PK2 (PK2Δ22, residues 23–215, Fig. 1) were successfully obtained and sufficient quality for X-ray structural analysis. The structural studies of the PK2 protein not only unravel the molecular basis for eIF2α kinase inhibition by PK2 but also help us to improving the ...

2002年8月1日 · Mutational analysis identifies two proximal regions of the K3L structure as possessing specialized PKR binding and inhibitory function. Further analysis reveals that PKR dimerization composes a key switch that regulates both its catalytic activation and its molecular recognition of K3L and eIF2α.

In this study, the Z-DNA-binding activity and stoichiometry of caZα PKZ were confirmed using circular dichroism (CD). In addition, preliminary X-ray studies of the caZα PKZ –Z-­DNA complex are reported as the first step in the determination of its three-dimensional structure.

2009年4月4日 · We have used small angle X-ray and neutron scattering to define the conformation of latent PKR in solution. Guinier analysis indicates a radius of gyration of about 35 Å. The p(r) distance distribution function exhibits a peak near 30 Å with a broad shoulder extending to longer distances.

The vaccinia virus protein K3L subverts the mammalian antiviral defense mechanism by inhibiting the RNA-dependent protein kinase PKR. K3L is a structural mimic of PKR's natural substrate, the translation initiation factor eIF2alpha.

2024年2月27日 · Here, we show that the exoribonuclease XRN1 is a negative regulator of the dsRNA sensor protein kinase R (PKR) in cancer cells with high interferon-stimulated gene expression. XRN1 deletion causes PKR pathway activation and consequent cancer cell lethality.