2020年8月8日 · p-IRE1α接下来会催化一个重要的过程：使Xbp1 mRNA发生剪切，形成一个功能活跃的转录因子Xbp1s。 Xbp1s进入细胞核后会启动一系列基因转录(如脂质合成、ERAD等)，从多个层次缓解内质网应激。

2020年7月1日 · XBP1 was first distinguished as a key regulator of major histocompatibility complex (MHC) class II gene expression in B cells. XBP1 communicates with the foremost conserved signalling component of the UPR and is essential for cell fate determination in response to ER stress (ERS).

2014年9月9日 · 可见 BiP 是内质网应激的关键性调控分子，其中 BiP 和 XBP-1 表达上调常被用作内质网应激的标志。 大量研究表明，发生内质网应激的细胞能调节内质网应激相关性促凋亡分子如 CHOP 和 caspase-12 等和促存活分子如 GADD34 和 BiP 等的表达 / 活化，最终决定细胞是适应 ...

2020年7月20日 · Activation of the IRE1/XBP1s signaling arm of the unfolded protein response (UPR) is a promising strategy to correct defects in endoplasmic reticulum (ER) proteostasis implicated in diverse...

2015年6月18日 · Accordingly, DC-specific XBP1 deletion or selective nanoparticle-mediated XBP1 silencing in tDCs restored their immunostimulatory activity in situ and extended survival by evoking protective type 1 anti-tumor responses.

2021年9月30日 · The expression of BiP (GRP78), spliced XBP1 (sXBP1, nuclear XBP1), and IRE1α, were significantly associated with Rhabdomyosarcoma (RMS) in the four main RMS subtypes: alveolar (ARMS), embryonal (ERMS), pleomorphic (PRMS) and sclerosing/spindle cell (SRMS) RMS; (n = 192) compared to normal skeletal muscle tissues (n = 16). There was a ...

2021年9月30日 · At the subtype level, BiP and sXBP1 expression were significantly associated with all subtypes of RMS, whereas IRE1α was associated with ARMS, PRMS and ERMS, and cytosolic XBP1 expression was associated with ARMS and SRMS.

2022年10月10日 · Activation of Ire1/Xbp1s up-regulates their downstream target Bip, which sequesters Yorkie (Yki), a Hippo pathway transducer, in the cytoplasm to restrict Yki transcriptional output. This regulation provides an endogenous defensive mechanism in organ size control, intestinal homeostasis, and regeneration.

Activation of Ire1/Xbp1s up-regulates their downstream target Bip, which sequesters Yorkie (Yki), a Hippo pathway transducer, in the cytoplasm to restrict Yki transcriptional output. This regulation provides an endogenous defensive mechanism in organ …

2025年3月5日 · Comparison with IRE1 and BIP: IRE1: Acts upstream by splicing XBP1 mRNA, so high IRE1 expression correlates with high nuclear XBP1 levels. BIP: Works as a molecular chaperone to regulate UPR activation. Cross-referencing BIP and XBP1 expression provides insights into UPR balance and adaptive vs. apoptotic responses. Therapeutic Implications: